Investigators

Principal Investigator and Director - Professor Alastair Florence

Pharmaceutical scientist with expertise in crystallisation and crystallisation screening of pharmaceuticals and other molecular solids and in approaches to the discovery, characterisation and control of physical forms including polymorphs, solvates, salts, co-crystals and amorphous solids. A key focus is on the physical analysis of crystalline and polycrystalline solids to study the influence of crystallisation conditions, processing, temperature and other factors on their structure and properties in pure and formulated states.

Tel: +44 (0)141 548 4877, Email: alastair.florence@strath.ac.uk

Co-Investigator – Dr Andrew J Alexander

Dr Andrew Alexander is a senior lecturer in chemical physics at The University of Edinburgh. The primary areas of interest for his research group are the interaction between light and matter. To this end we use polarized laser light to both stimulate chemical processes and to study the resulting structures and dynamics. Further information can be obtained from Dr Alexander’s group pages.

E-mail: a.alexander@ed.ac.uk

Co-Investigator - Professor Lee Cronin

Cronin's research focuses on the assembly of complex chemical, colloidal and crystalline systems. Projects are based around the assembly of nanoscale systems, non-equilibrium supramolecular assembly, dissipative chemical systems, chemical evolution in flow-systems, symmetry breaking for the processing of new products and feedback control and chemical engineering systems.

Tel: +44 (0)141 330 6650, E-mail: L.Cronin@chem.gla.ac.uk

Co Investigator - Professor Gavin Halbert

Pharmaceutical scientist and Director of the Cancer Research UK Formulation Unit involving the analytical development, pre-formulation, formulation, manufacture and distribution of putative cytotoxic agents for Phase I and II clinical trial. Research interests based around this activity and ranging through formulation, drug targeting and pharmaceutical microbiology.

Tel: +44 (0)141 548 2454, E-mail: g.w.halbert@strath.ac.uk

Co-Investigator – Dr Blair Johnston

Dr Blair Johnston is a Senior Lecturer in Computational Modelling at the Strathclyde Institute of Pharmacy and Biomedical Sciences. His group has research interests in five broad areas: drug discovery, molecular structure simulation, machine learning and prediction, data analysis, and web-enabled science and collaboration tools. In the vast majority of Dr Johnston’s research, he works closely with experimental scientists in the design and execution of collaborative research to realise the full potential of their laboratory data. This combination of experiment and theory often provides unique insight into the systems being studied. Dr Blair Johnston is also a Co-Investigator on the CMAC–ICT grant.

Tel: +44 (0)141 548 5756, E-mail: blair.johnston@strath.ac.uk

Co-Investigator - Dr Dimitrios Lamprou

Dr Dimitrios A. Lamprou is a Lecturer in Pharmaceutical Sciences at the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). His group has research interests in four broad areas: Advanced Drug Delivery Systems, AFM NanoAnalysis, Biosurfaces, and Hot-melt Extrusion (HME). Especially in the areas of formulation, PAT solutions, printing of 3D Structures, twin-screw extrusion for wet granulation, antifouling coatings, and Micro- and Nanoscale studies of nucleation, growth and dissolution of crystals. Dr Lamprou is also the course director of the MSc in Advanced Pharmaceutical Manufacturing.

Tel: +44 (0)141 548 4968, E-mail: dimitrios.lamprou@strath.ac.uk

Co-Investigator - Professor David Littlejohn

Philips Professor of Analytical Chemistry
Analytical chemist with interests in in situ and non-invasive measurement techniques and data analysis methods for real-time monitoring and optimisation of reactions and manufacturing processes.

Tel +44 (0)141 548 2067, E-mail: d.littlejohn@strath.ac.uk

Co-Investigator - Professor Zoltan K Nagy

Research interests include: pharmaceutical systems engineering, modelling, monitoring, optimization and control (model-based and model-free) of crystallization systems (crystal size distribution, shape and polymorphic form), population balance modelling and process analytical technologies.

Tel: +44 (0)1509 222516, E-mail: z.k.nagy@lboro.ac.uk

Co-Investigator - Professor Xiong-Wei Ni

Chemical Engineer with expertise in mixing, dispersion, reactions and crystallisation in continuous flow reactors I am the leading expert in oscillatory baffled flow mixing, reaction and crystallisation. Oscillatory baffled reactors and crystallisers are the initial core technologies in CMAC.

Tel: +44 (0)131 451 3781, E-mail: x.ni@hw.ac.uk

Co-Investigator - Dr Alison Nordon

A senior Lecturer in Pure and Applied Chemistry at the University of Strathclyde with interests in in-situ and non-invasive measurement techniques, chemoinformatics and data analysis techniques for real-time monitoring and understanding of process systems.

Tel: +44 (0)141 548 3044, E-mail: alison.nordon@strath.ac.uk

Co-Investigator - Prof Colin Pulham

High-pressure studies on the crystal structures of pharmaceutical compounds and energetic materials (explosives and propellants). Recovery of high-pressure forms to ambient conditions. Co-crystallisation of energetic compounds to give materials with enhanced properties e.g. reduced sensitivity. Crystallisation of phase change materials for heat storage.

Tel: +44 (0)131 650 4756, E-mail: c.r.pulham@ed.ac.uk

Co-Investigator - Professor Chris Rielly

As Chemical Engineers, we will use PAT tools to monitor and control nucleation and growth in continuous flow crystallisers, to achieve a target size distribution and morphology of a particulate product. In addition, we will use combinations of computational fluid dynamics and population balances to model these processes and hence to explore optimal operating conditions

Tel: +44 (0)1509 222504, E-mail: c.d.rielly@lboro.ac.uk

Researcher - Dr Jag Srai

Research interests: International Supply Chains; Supply Network Design - International firms and Multinational Corporations; Supply Chain Capability - Capability Models; Supply Chain Configuration - Influence on capability and performance; Service Supply Chain operations; Value chain analysis & mapping techniques; Sustainable supply chain design.

Tel: +44 (0)1223 765601, E-mail: jss46@cam.ac.uk

Co-Investigator - Prof Jan Sefcik

My research is at the interface of chemical engineering and physical chemistry, dealing with crystalline, colloidal, and nanoscale materials. The main focus is on particle formation mechanisms (nucleation), characterisation and optimisation of nanostructures (scattering) and scale up under continuous conditions (flow effects).

Tel: +44 (0)141 5482410, E-mail: jan.sefcik@strath.ac.uk

Co-Investigator – Prof Joop H. ter Horst

Prof ter Horst performs application driven fundamental research on separation processes in order to recognize new tools in the separation technology toolbox of the future. He identifies new driving forces, new hybrid processes and new multicomponent materials for separations by targeting key scientific questions on the interplay between solution thermodynamics, mass transfer limitations, and complex products. He adopts a view from the molecular level and up for gaining macroscopic understanding to use in control and prediction of new industrial separation processes.

Tel: +44 (0)141 548 2858, E-mail: joop.terhorst@strath.ac.uk

Co-Investigator - Professor Chick Wilson

Chick carries out research in structural chemistry, designing and engineering intermolecular interactions to assemble molecules into the solid state, targeting materials with potential applications in optics, electronics and pharmaceuticals. Crystallisation is used extensively in his work as a route to new materials and to control molecular assembly of known materials.

Tel: +44 (0)1225 386143, E-mail: C.C.Wilson@bath.ac.uk

Co-Investigator - Professor Sir Mike Gregory

Professor Sir Mike Gregory is Head of the Manufacturing and Management Division of the University Engineering Department and of the Institute for Manufacturing (IfM). His involvement with CMAC reflects his broad view of manufacturing and his ability to link science, engineering, management and economics and integrating education, research and practice.

Email: mjg@eng.cam.ac.uk