Image Credit: ARTICULAR: ARtificial inTelligence for Integrated ICT-enabled pharmaceUticaL mAnufactuRing (EP/R032858/1).
CMAC are excited to announce the new £1.2M award from EPSRC to lead the new international collaboration for Digital Design and Manufacture of Amorphous Pharmaceuticals (DDMAP).
This award brings together three world-leading research groups from the UK (CMAC, University of Strathclyde), Denmark (CPHarma, University of Copenhagen) and Belgium (CESPE, Ghent University) to deliver a step change in fundamental understanding of amorphous materials that will apply to real industrial challenges in medicines manufacturing. This unique centre will create a dynamic collaboration across Europe that will embrace open science and offer multi-disciplinary and multi-organisational research engagement.
DDMAP has a collaborative mission to develop new science and methodologies that will de-risk the use of amorphous solid forms, reduce the cost of their development and manufacture, and accelerate the adoption of this versatile and effective solid form in the pharmaceutical industry. DDMAP is supported by each of the three leading research groups alongside significant project partners including AstraZeneca, Sandoz and CCDC. The international centre will address key research questions that underpin the selection, production and application of amorphous molecular solids as well as establish a collaborative, world-leading network across Europe with expertise in medicines development and manufacture.
Prof Alastair Florence, PI of the DDMAP international centre to centre award said: “This is a fantastic opportunity to collaborate between three leading centres across Europe and address challenges that limit the more routine exploitation of this important class of pharmaceutical materials. The multidisciplinary team will develop new understanding on the structure, transformations, processing and performance of amorphous systems through a unique international collaboration. Not only will we be building new knowledge, but working together to create an innovative open access data resource that will allow others to benefit from the project as well as supporting the development of the next generation of research leaders in this field.”
The team working to deliver the DDMAP international centre aims include Dr Cameron Brown, Prof Blair Johnston, Dr Andrea Johnston, Dr Daniel Markl and Dr John Robertson (Strathclyde), Prof Jukka Rantanen, Prof Thomas Rades and Prof Anette Müllertz (Copenhagen), and Prof Thomas De Beer and Prof Ashish Kumar (Ghent).
For more information and to find out how to engage with the centre, please contact Prof Alastair Florence: alastair.florence@strath.ac.uk.
Further information on the scheme:
Digital Design and Manufacture of Amorphous Pharmaceuticals (DDMAP) is one of 12 international collaborations to develop the technologies of tomorrow.
https://www.ukri.org/news/international-collaborations-to-develop-technologies-of-tomorrow/
Image Credit: UKRI
CMAC are delighted to announce a new £5M award from EPSRC to establish and lead the new Made Smarter Innovation - Digital Medicines Manufacturing Research Centre (DM2). This award continues to build CMAC’s research portfolio and is part of the UKRI and Made Smarter Innovation £53 million investment in smart manufacturing and connected supply chain research and innovation.
DM2 is led by the University of Strathclyde (CMAC) in partnership with Loughborough and Cambridge Universities and is supported by a vibrant consortium of 28 project partners from across specialty pharma, digital software and hardware providers, robotics, simulation tools and pharmaceutical technology. The collaborating partners are contributing over £2.9M to co-create and co-deliver the research. The Centre’s goal is to accelerate the adoption of industry digital technologies (IDTs) across the pharma sector and transform data driven medicines development and manufacture. The Centre will address patient needs through establishing a foundational data platform, autonomous robotic oral medicine development and manufacturing system, a revolutionary digital quality control (QC) capability, investigate on demand patient-centric supply and develop and empower the digitally literate workforce of the future.
Prof Alastair Florence, PI of the DM2 Research Centre said: “This fantastic news allows us to address key challenges in the digitalisation of medicines development, manufacture and supply. We aim to unleash the potential impact of IDTs across the value chain to dramatically reduce waste, lead times and quality control costs, increase productivity and enhance the agility and efficiency of clinical trial supply chains, vital to the introduction of new therapies. Our impact focussed programme will benefit not only manufacturing industry and healthcare providers but also, ultimately, patients.”
“These ambitious targets demand a transformation in the way that data across pharma's supply chain are captured, stored, shared, processed, modelled and used. The integrated research test beds in DM2 will connect data, IDTs and drug product manufacturing processes to deliver this transformation.”
The Research Centre will also work with the community to drive the cultural change and skills development required to support IDT adoption. Prof Florence explained “The award will support the DM2 network to engage users in all stages of research, showcase the value of data and IDTs and encourage innovation. Working with stakeholders we will identify training needs to drive data literacy and enable the future, augmented workforce that trust data and IDTs and convert data into knowledge into action.”
The team working with the PI to deliver the DM2 Research Centre aims include the Industry Engagement Lead, Massimo Bresciani and Platform leads Prof Blair Johnston, Dr Daniel Markl and Dr Andrea Johnston (Strathclyde), Dr Brahim Benyahia (Loughborough) and Dr Jag Srai (Cambridge).
For more information and to find out how to engage with the programme, please contact Prof Alastair Florence: alastair.florence@strath.ac.uk.
Further information on the scheme:
The Made Smarter Innovation - Digital Medicines Manufacturing Research Centre is one of 5 University led research centres that will receive a share of £25 million to help the UK’s manufacturing industry become more productive and competitive through innovation and adoption of digital technologies. As well as being at the forefront and driving developments in their areas of expertise, these research centres will connect across the challenge to help bridge the gap between basic research and its application in manufacturing to provide a pipeline of digital technologies for the future.
https://www.ukri.org/news/funding-awarded-to-boost-uk-manufacturing-supply-chains/
https://www.strath.ac.uk/whystrathclyde/news/strathclydepartnersintwonewukmanufacturingresearchcentres/
February’s meeting, jointly run between MIT and CMAC Future Manufacturing Research Hub, brought together over 350 pharmaceutical industrialists, regulators, policy makers and academics from more than 22 countries and 142 organisations to inform strategies to grow medicines manufacturing in the UK and internationally, through accelerating the adoption of advanced manufacturing and digital technologies.
The UK already benefits from an excellent research base, investments in innovation centres, leading pharmaceutical manufacturers, dynamic technology and supply chain partners and a leading, independent national regulator, the MHRA. Given the strategic importance and opportunities for growth in the medicines manufacturing sector, a number of recommendations are made to strengthen the UK’s position as a leading location to develop, design, manufacture and supply medicines.
The full document and recommendations across industry, academia and regulatory can be viewed here.
This meeting was hosted by the joint MIT CMAC ISCMP Steering Team. Registration and attendance was at no charge to participants.
Continuous flow chemical reactor manufacturer Laminar Co Ltd (Jungwon-gu, Republic of Korea), represented in the UK and Ireland by Analytik Ltd (Cambridge, UK), have joined the CMAC Future Manufacturing Research Hub as tier 2 members from October 2020.
Laminar manufactures the world’s first commercially available chemical reactors which utilise Taylor Fluid Flow to synthesize high-purity, uniform substances. The patented design chemical reactors use a jacketed cylindrical vessel with a central, rotating agitation bar to produce Taylor Flow mixing along the length of the vessel resulting in 3-times faster mass flow transfer compared to tank type reactors.
The partnership will see the first Taylor Flow Reactor installed in the UK at CMAC’s Technology Innovation Centre (TIC) site in Glasgow, which will initially be studied to greater understand the mechanisms and potential of the technology, explore new syntheses and be benchmarked against existing processes. The CMAC Future Manufacturing Research Hub brings together a research team at Strathclyde, as well as other leading academic groups and an array of industry partners to address the urgent need to translate new molecules into high-value products through rapid predictive development pathways and integrated continuous manufacturing systems.
Analytik announced a partnership with Laminar to distribute their Taylor Flow Reactors in the UK and Ireland in 2019. Specialists in providing and supporting pioneering technology, it will oversee the installation of a Tera3100-HC Laminar Continuous Taylor Reactor (LCTR®) at CMAC in early 2021, as well as provide ongoing technical and service support over 3 years.
Speaking about the membership, Ian Laidlaw, Managing Director at Analytik said “We are delighted to be joining the CMAC Future Manufacturing Research Hub and excited to be facilitating the first LCTR® chemical reactor installation in the UK. This fantastic technology sets a new standard for high yield synthesis of high-purity, uniform substances and offers faster, more efficient continuous processing”.
Professor Alastair Florence, Director of CMAC added “It is a pleasure to welcome Laminar and Analytik to CMAC’s community. This partnership brings exciting new opportunities for our research team to work with this unique Taylor Flow Reactor platform to explore the potential for this advanced technology across reaction, work-up, purification and particle engineering for pharmaceutical systems. This technology will extend our Digital Twin and MicroFactory platforms for continuous manufacturing and create real benefits and impacts to our stakeholders though enabling faster process and product development and reducing the cost and environmental impact of medicines manufacture.”
You can find out more about Laminar Continuous Taylor Reactors (LCTR) by visiting the Analytik website: https://analytik.co.uk/product/continuous-flow-reactor/.
The LCTR®-Tera 3100 & 3300.
ABOUT CMAC
The CMAC Future Manufacturing Research Hub will address the urgent need to translate new molecules into high-value products through rapid predictive development pathways and integrated continuous manufacturing systems, enabling more personalised, responsive and flexible product provision through digitalised supply chains. Building on the significant success of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, and informed by extensive engagement with national and global industry, end-users, technology providers, international academic programmes and regulatory agencies, the industry-academic team has co-created an ambitious CMAC Future Manufacturing Research Hub Vision. www.cmac.ac.uk
ABOUT ANALYTIK
For over 15 years Analytik has been a trusted supplier of cutting-edge scientific instrumentation to leading organisations throughout the UK and Ireland. Specialists in providing and supporting pioneering technology, it delivers added value through specialised consultative expertise and comprehensive pre- and post-sales support to ensure that customers get the most out of their investment. For further information please visit http://analytik.co.uk/.
ABOUT LAMINAR
Founded in 2010, South Korean-based Laminar has patented the world’s first commercially available Taylor Flow Reactor (LCTR®) and continues to develop manufacturing processes and expand its product range, which can be applied to various fields, such as secondary batteries, pharmaceuticals, graphene oxide, food additives and nanomaterials.
CONTACT
Karina Davies, Analytik – karina.davies@analytik.co.uk
Stewart Mitchell, CMAC – stewart.mitchell@strath.ac.uk
Funding Announcement: Digital Design and Manufacture of Amorphous Pharmaceuticals (DDMAP)
CMAC are excited to announce the new £1.2M award from EPSRC to lead the new international collaboration for Digital Design and Manufacture of Amorphous Pharmaceuticals (DDMAP).
This award brings together three world-leading research groups from the UK (CMAC, University of Strathclyde), Denmark (CPHarma, University of Copenhagen) and Belgium (CESPE, Ghent University) to deliver a step change in fundamental understanding of amorphous materials that will apply to real industrial challenges in medicines manufacturing. This unique centre will create a dynamic collaboration across Europe that will embrace open science and offer multi-disciplinary and multi-organisational research engagement. .... more
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