| Title | Continuous manufacturing of liposome formulations incorporating anti-cancer agents: Exploiting novel methods in microfluidics. |
|---|---|
| Supervisors | Yvonne Perrie Zahra Rattray |
| Research Area | Advanced manufacturing (Y Perrie); Drug Delivery (Health and Wellbeing – Y Perrie, Z Rattray); Particle Characterization (Measurement and Enabling Technologies, Z Rattray) |
| Description | This interdisciplinary project is designed to consider the development of appropriate systems to manufacture liposome-based drug delivery and will be based within two of our research groups: (Prof Perrie and Dr Rattray). The research is focused on developing new formulations and new processes for the production of liposomes for the delivery of anti-cancer agents. The project will investigate a range of small molecules for the treatment of cancer and will investigate their formulation into a range of liposome systems. Nanotechnology will be exploited to improve cellular targeting allowing for improved drug efficacy and reduced side effect profiles. The biological actions and interactions will also be investigated. A range of pharmaceutical analysis tools will be used to investigate and characterise the new compounds and a suite of manufacturing facilities will be used to formulate, characterise and optimise the formulations to improve drug targeting. |
| Techniques Used | This project will involve a range of liposomal formulations. These systems will be formulated and optimised for their drug loading potential and then surface functionalised to exploit effective targeting strategies. |
| References | 1. Roces CB, Khadke S, Christensen D, Perrie Y (2019). Scale-independent microfluidic production of cationic liposomal adjuvants and development of enhanced lymphatic targeting strategies. Mol Pharm. 2019 Aug 22. doi: 10.1021/acs.molpharmaceut.9b00730. [Epub ahead of print] 2. Lou Ramirez, G., Anderluzzi, G., Woods, S., Roberts, C. & Perrie, Y. (2019). A novel microfluidic-based approach to formulate size-tuneable large unilamellar cationic liposomes: formulation, cellular uptake and biodistribution investigations. Eur J Pharm Biopharm. 143:51-60. https://doi.org/10.1016/j.ejpb.2019.08.013 3. Khadke S, Roces CB, Cameron A, Devitt A, Perrie Y. (2019). Formulation and manufacturing of lymphatic targeting liposomes using microfluidics. J Control Release. 307:211-220. doi: 10.1016/j.jconrel.2019.06.002. 4. Wahlich J, Desai A, Greco F, Hill K, Jones AT, Mrsny RJ, Pasut G, Perrie Y, Seib FP, Seymour LW, Uchegbu IF. (2019). Nanomedicines for the Delivery of Biologics. Pharmaceutics. 11(5). pii: E210. doi:10.3390/pharmaceutics11050210. |
| Conditions | Applicants should possess or be about to obtain a 1st class or 2:1 Honours degree or equivalent in a relevant discipline in addition to receipt of satisfactory references and an IELTS score of 6.5 where appropriate. We encourage highly-competitive and motivated students with an interest in the pharmaceutical industry and a background in chemical engineering or pharmaceutical sciences to apply for this project. |
| Bench Fee | Running costs of £10000 p.a. will be associated with this project in addition to University tuition fees. This project is open to self-funding students or students who already hold funding support (e.g. The Ministry/Department of Education/British Council). |
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