SIPBS - Staff

Bobat S, Flores-Langarica A, Hitchcock J, Marshall JL, Kingsley RA, Goodall M, Gil-Cruz K, Serre K, Leyton D, Letran SL, Gaspal F, Chester R, Dougan G, L�pez-Mac�as C, Henderson IR, Alexander J, MacLennan ICM, Cunningham AF (2011) Soluble flagellin, FliC, induces an antigen-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella Typhimurium infection.. Journal of Immunology 41, 1606-1618

Emma McFarlane, Katharine C. Carter, Andrew N. McKenzie, Paul M. Kaye, Frank Brombacher and James Alexander (2011) Endogenous IL-13 plays a crucial role in liver granuloma maturation during Leishmania donovani infection, independent of IL-4Ra-responsive macrophages and neutrophils. Journal of Infectious Diseases 204, 36-43 [DOI: 10.1093/infdis/jir080 ]

Menzies FM, Henriquez FL, Alexander J, Roberts CW (2011) Selective inhibition and augmentation of alternative macrophage activation by progesterone.. Immunology 134, 281-291 [DOI: 10.1111/j.1365-2567.2011.03488.x.]

Muhannad Shweash, Adrienne McGachy, Juliane Schroeder, Thikyrat Neamatallah, Clare Bryant, Owain Millington, Jeremy Motram, James Alexander and Robin Plevin (2011) Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and Arginase 1 expression. Molecular Immunology , Published (Epub)

Al-Mutairi MS, Cadalbert LC, McGachy HA, Shweash MS, Schroeder J, Kurnik M, Sloss CM, Bryant CE, Alexander J and Plevin R (2010) MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLoS Pathogens 6, e1001192

Jones LA, Kreem S, Shweash M, Paul A, Alexander J, Roberts CW. (2010) Differential modulation of TLR3- and TLR4-mediated dendritic cell maturation and function by progesterone. Journal of Immunology 185, 4525-4534

Jones LA, Roberts F, McKenzie ANJ, Henriquez FL, Alexander J and Roberts C.W. (2010) IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii. European Journal of Immunology 40, 426-436

Karen J. Bryson, Owain R. Millington, Thabang Mokgethi H. Adrienne McGachy, Frank Brombacher and James Alexander (2010) BALB/c mice deficient in CD4 T cell IL-4Rα expression control leishmania mexicana Load although female but not male mice develop a healer phenotype. PLOS Neglected Tropical Diseases 5, e930

Millington OR, Myburgh E, Mottram JC, Alexander J. (2010) Imaging of the host/parasite interplay in cutaneous leishmaniasis.. Experimental Parasitology 126, 310-317

Alexander J, Irving K, Snider H, Satoskar A (2009) Sex hormones and regulation of host responses against parasites in "Sex hormones and Immunity to Infection" Eds Sabra L Klein and Craig W Roberts Springer Verlag Heidelberg Berlin Chapter 6, 147-186. Book Chapter ,

Bryson K, Besteiro S, McGachy HA, Coombs GH, Mottram JC, Alexander J. (2009) Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response. Infection and Immunity 77, 2971-2978 [DOI: 10.1128/IAI.00558-08]

Graham D, Faulds K, Thompson D, McKenzie F, Stokes R, Dalton C, Stevenson R, Alexander J, Garside P, McFarlane E. (2009) Functionalised nanoparticles for bioanalysis by SERRS. Biochemical Society Transactions 37, 697-701 [DOI: 10.1042/BST0370697]

Henriquez S.A., Brett R., Alexander J., Pratt J., Roberts C.W. (2009) Neuropsychiatric disease and Toxoplasma gondii infection. Neuroimmunomodulation 16, 122-133 [DOI: 10.1159/000180267 ] Published (review)

Mann JF, Shakir E, Carter KC, Mullen AB, Alexander J, Ferro VA. (2009) Lipid vesicle size of an oral influenza vaccine vehicle influences the Th1/Th2 bias in the immune response and protection against infection. Vaccine 27, 3643-3649 [DOI: 10.1016/j.vaccine.2009.03.040]

Menzies, F., Henriquez,, F.L., Alexander, J. and ROBERTS, C.W. (2009) Sequential expression of macrophage antimicrobial/inflammatory and wound healing markers following innate, alternative and classical activation. Clinical and Experimental Immunology 160, 369-379

Sneider H., Lezama-Davila C., Alexander J., Satoskar A.R. (2009) Sex hormones and Modulation of Immunity against leishmaniasis.. Neuroimmunomodulation 16, 106-113 [DOI: 10.1159/000180265] Published (review)

Stokes R.J., McKenzie F., McFarlane E., Ricketts, A., Tetley L., Faulds K., Alexander J., Graham D. (2009) Rapid cell mapping using nanoparticles and SERRS. Analyst 134, 170-175 [DOI: 10.1039/b815117b]

Alexander J., McFarlane E (2008) Can type-1 responses against intracellular pathogens be T helper 2 cytokine dependent?. Microbes and Infection 10, 953-959 [DOI: 10.1016/j.micinf.2008.07.038] Published (review)

Bryson K.J., Wei XQ., Alexander J. (2008) Interleukin-18 Enhances a Th2 biased response and Susceptibility to Leishmania mexicana in BALB/c mice. Microbes and Infection 10, 834-839 [DOI: 10.1016/j.micinf.2008.03.009]

Jones L.A., Anthony J.P., Henriquez F.L., Lyons R.E., Nickdel M.B., Carter K.C., Alexander J., Roberts C.W. (2008) Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors Immunology. Immunology 125, 59-69

McFarlane E, Perez C, Chamoy M, Allenbach C, Carter K.C. Alexander J, Tacchini-Cottier F. (2008) Neutrophils contribute to development of a protective immune response during onset of infection with Leishmania donovani.. Infection and Immunity 76, 523-541

Michels C., Scales H., Saunders K., McGowan S., Brombacher F., Alexander J., Lawrence C. (2008) Neither IL-4Ra expression on CD4+ T cells, nor macrophages and neutrophils is required for protective immunity to Trichinella spiralis. Immunology 128, 385-394 [DOI: 10.1111/j.1365-2567.2008.02987.x]

Alexander, Prof J., Brombacher, F., Cutler, A.J., Hoving, J.C., Magez, S., Holscher, C., Bohms, A., Arendse, B., Kirsch, r., Hunig, T., Kaye, P., Radwanska, M., (2007) Deletion of IL-4Ra on CD4 T Cells Renders BALB/c Mice Resistant to Leishmania major Infection. PLoS Pathogens 3, e68 [DOI: 10.1371/journal.ppat.0030068 ]

Alexander, Prof J., Radwanska, m., Cutler, A.J., Hoving, J.C., Magez, S., Holscher, C., Bohms, A., Arendse, B., Kirsch, r., Hunig, T., Kaye, P., Brombacher, F., (2007) Deletion of IL-4R? on CD4 T Cells Renders BALB/c Mice Resistant to Leishmania major Infection. PLoS Pathogens 3, e68 [DOI: 10.1371/journal.ppat.0030068 ]

Alexander, Prof J., Carter, Dr K.C., Ferro, Dr V.A., Mullen, Prof A., (2006) Translation of an experimental oral vaccine formulation into a commercial product. Methods 38, 65-68 [DOI: 10.1016/j.ymeth.2005.11.001 ]

Alexander, Prof J., Carter, Dr K.C., Ferro, Dr V.A., Mullen, Prof A., Mann, Mr J.F.S., Scales, Miss H.E., Shakir, Ms E., (2006) Oral delivery of tetanus toxoid using vesicles containing bile salts (bilosomes) induces significant systemic and mucosal immunity. Methods 38, 90-95 [DOI: 10.1016/j.ymeth.2005.11.002 ]

Alexander, Prof J., Graham, Prof D., (2006) New Probes and Optical Spectroscopies for Immune Parasitological Applications. Parasite Immunology 28, 236-237 [DOI: 10.1111/j.1365-3024.2006.00841.x ]

Alexander, Prof J., Roberts, Dr C.W., Jones, L.A., (2006) Ocular toxoplasmosis: in the storm of the eye. Parasite Immunology 28, 635-642 [DOI: 10.1111/j.1365-3024.2006.00874.x ]

Alexander, Prof J., Paul, Dr A., Plevin, Prof R.J., McGachy, Mrs H.A., Cameron, Dr P., Mottram, J.C., Coombs, G.H., Anderson, M., (2004) Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway.. Journal of Immunology 173, 3297-3304

Stimson, Prof W.H., Alexander, Prof J., Carter, Dr K.C., Ferro, Dr V.A., Mullen, Prof A., Mann, Mr J.F.S., Tetley, L., Mullen, M., (2004) Optimisation of a lipid based oral delivery system containing A/Panama influenza haemagglutinin. Vaccine 22, 2425-2429 [DOI: 10.1016/j.vaccine.2003.11.067 ]

Alexander, Prof J., Brombacher, F., Stager, S., Kirby, A.C., Botto, M., Van Rooijen, N., Smith, D.F., Kaye, P.M., (2003) Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T cell responses. Nature Medicine 9, 1287-92 [DOI: 10.1038/nm933 ]

Alexander, Prof J., Lyons, Dr R., McNeil, Ms K., Coombs, Prof G.H., Mottram, J.C., Pollock, K.G.J., Brewer, J.M., Scott, P., (2003) The Leishmania mexicana Cysteine Protease, CPB2.8, Induces Potent Th2 Responses. Journal of Immunology 170, 1746-53

Alexander, Prof J., Padigel, U.M., Farrell, J.P., (2003) The Role of Interleukin-10 in Susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis. Journal of Immunology 171, 3705-3710

Alexander, Prof J., Carter, Dr K.C., Walker, Dr W., Brombacher, F., McGachy, H.A., McKenzie, A.N.J., (2002) An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection. European Journal of Immunology 32, 2923-2933

Alexander, Prof J., Roberts, Dr C.W., Anthony, Mr J., Lyons, Dr R., Ferguson, D.J.P., Roberts, F., Byrne, N., (2001) Immunological studies of chronic ocular toxoplasmosis: upregulation of MHC class I and TGF-beta?and a protective role for IL-6.. Infection and Immunity 69, 2589-2595 [DOI: 10.1128/IAI.69.4.2589-2595.2001 ]

Alexander, Prof J., Roberts, Dr C.W., Nickdel, Dr M.B., Roberts, F., Brombacher, F., (2001) Counter-protective role for interleukin-5 during acute Toxoplasma gondii infection. Infection and Immunity 69, 1044-52 [DOI: 10.1128/IAI.69.2.1044-1052.2001 ]

Professor James Alexander

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