Professor of Parasite Immunology
Tel : +44(0)141 548 3925 (Ext. 3925)
Our laboratory specialises in studying the interaction of the immune system with intracellular protozoan parasites, particularly Leishmania and Toxoplasma gondii. The use of cytokine, cytokine receptor, costimulatory molecule, and signaling molecule gene deficient mice is currently providing a very powerful tool in the analysis of immunoregulatory control of parasitic disease. We have recently further expanded our studies to utilize 2nd generation gene reporter as well as cytokine receptor tissue/cell specific knockouts. Of particular interest to our group is is the development of vaccines against these parasites using recombinant antigen preparations and gene deficient mutants. The development and characterisation of novel adjuvants for use with modern technology vaccines is a particular area of expertise within the group. The development of vaccine delivery formulations, which function as well as orally as they do parenterally is an area of top priority.
We have pioneered studies on the immunopathology of Toxoplasma gondii particularly in the central nervous system and characterised a laboratory model of congenital toxoplasmosis suitable for testing vaccines and chemotherapeutic agents. How these immune responses to parasite infection are influenced by gender and sex hormones is an area of particular interest.
Ongoing collaborations with the Universities of Glasgow, York, Birmingham, Cape Town, Lusanne and Chicago complement these studies.
"Towards a vaccine for Toxoplasmosis"
National Institute for Health (NIH)
"Establishment of a biophotonic imaging system for in vivo biology "
"In vivo reporting using nanosystems chemistry and optical spectroscopy"
EPSRC Engineering and Physical Sciences Research Council
"The cellular basis and pathogenic consequences of mitogen-activated protein kinase phosphatise-2 regulation of innate and adaptive immunity"
Dr Farzana Khaliq: 'Towards a vaccine for Toxoplasmosis' (started 2008)
Dr Thabang Mokgethi (started 2010)
Dr Lesley Morrison: 'Establishment of a biophotonic imaging system for in vivo biology' (started 2010)
Dr Julianne Schroeder: 'The cellular basis and pathogenic consequences of mitogen-activated protein kinase phosphatise-2 regulation of innate and adaptive immunity' (started 2010)
Tirth Raj Ghimire: 'Investigating the contributions of inflammation and antigen depot to adjuvant function in vivo' (started 2008)
Selina Anne Henriquez: 'Relationship between Toxoplasma gondii and psychiatric disorders' (started 2008)
Karen Irving: 'The role of IL-33 during toxoplasma infection' (started 2007)
Shrook Kreem: 'Immunoendocrine Control of Toxoplasma gondii infection' (started 2008)
Susan Manson: 'The role of MAK2 during intracellular infection' (started 2009)
Thikryat Abdullatef A Neamatallah: 'The role of MKP-2 in leishmania infection - the role of dendritic cells' (started 2010)
Muhannad Abdulmajeed Muhammad Shweash (started 2008)
Stuart Woods: 'Vaccine development for Toxoplasma gondii' (started 2008)