Tel : +44(0)141 548 2819 (Ext. 2819)
Research in my group is focussed on the actinobacteria. These are a major bacterial clade in the 16S phylogenetic tree, contributing 10-30% of the prokaryotic flora in most environments. They are a group of high-GC Gram-positive bacteria whose members are of interest because of their huge industrial importance and because of their pathogenicity towards humans. The primarily soil dwelling genus Streptomyces is responsible for producing around two thirds of all commercially important antibiotics as well as numerous anti-fungal, anti-helminthic and anti-cancer drugs. Pathogenic actinomycetes include Mycobacterium leprae, the causative agent of Leprosy and Mycobacterium tuberculosis, the aetiological agent of Tuberculosis, responsible for two million human deaths worldwide each year. The corynebacteria include the important industrial microorganism Corynebacterium glutamicum, which is used to produce tonnes of amino acids every year, and the human pathogen Corynebacterium diptheriae, the causative agent of Diphtheria; and more recently emerging infections caused by non-toxogenic C. diptheriae.
We use a range of techniques to study the biology of actinomycetes including molecular genetics, protein biochemistry, genomics, microscopy, physiology, mathematical modeling, spectroscopy and bioinformatics.
Please visit my lab webpage
"New Tools for Biomolecular Characterisation: Ultrafast 2D-IR Spectroscopy"
The Leverhulme Trust
"Non-toxigenic Corynebacterium diptheriae; a pathogen of emerging importance in Scotland"
Medical Research Scotland
Laura Clark : 'Elucidating the role of conserved gene clusters in actinomycetes' (started 2007)
Khanungkan Klanbut: 'The role of phospholipids in the growth and development of Streptomyces Coelicolor' (started 2009)
Leena Nieminen : 'Modelling metabolic switching in the differentiating bacterium streptomyces coelicolor' (started 2008)
Richard Alexander Reumerman: 'A novel systems approach to link primary and secondary metabolism during antibiotic production ' (started 2010)
Lewis Stewart: 'Transcriptional profiling of a pseudomonas aeruginosa - nematode infection model' (started 2010)
Charles Fredrik Webb: 'Phospholipid-protein interactions in streptomyces coelicolor' (started 2010)