Profile
Research in my group is focussed on the actinobacteria. These are a major bacterial clade in the 16S phylogenetic tree, contributing 10-30% of the prokaryotic flora in most environments. They are a group of high-GC Gram-positive bacteria whose members are of interest because of their huge industrial importance and because of their pathogenicity towards humans. The primarily soil dwelling genus Streptomyces is responsible for producing around two thirds of all commercially important antibiotics as well as numerous anti-fungal, anti-helminthic and anti-cancer drugs. Pathogenic actinomycetes include Mycobacterium leprae, the causative agent of Leprosy and Mycobacterium tuberculosis, the aetiological agent of Tuberculosis, responsible for two million human deaths worldwide each year. The corynebacteria include the important industrial microorganism Corynebacterium glutamicum, which is used to produce tonnes of amino acids every year, and the human pathogen Corynebacterium diptheriae, the causative agent of Diphtheria; and more recently emerging infections caused by non-toxogenic C. diptheriae.
We use a range of techniques to study the biology of actinomycetes including molecular genetics, protein biochemistry, genomics, microscopy, physiology, mathematical modeling, spectroscopy and bioinformatics.
Please visit my lab webpage
"New Tools for Biomolecular Characterisation: Ultrafast 2D-IR Spectroscopy"
The Leverhulme Trust
"Non-toxigenic Corynebacterium diptheriae; a pathogen of emerging importance in Scotland"
Medical Research Scotland
Publications
- Katrin Adamczyk, Marco Candelaresi, Kirsty Robb, Andrea Gumiero, Martin A Walsh, Anthony W Parker, Paul A Hoskisson, Nicholas P Tucker, and Neil T Hunt. (2012) Measuring protein dynamics with ultrafast two-dimensional infrared spectroscopy.. MEASUREMENT SCIENCE & TECHNOLOGY 23, 062001 [DOI: 10.1088/0957-0233/23/6/062001] Published (review)
- Katrin Adamczyk, Marco Candelaresi, Rafal Kania, Kirsty Robb, César Bellota-Antón, Gregory M Greetham, Mark R Pollard, Michael Towrie, Anthony W Parker, Paul A Hoskisson, Nicholas P Tucker, and Neil T Hunt.
(2012) The effect of point mutation on the equilibrium structural fluctuations of ferric Myoglobin.. PHYSICAL CHEMISTRY CHEMICAL PHYSICS 14, 7411-7419 [DOI: 10.1039/c2cp23568d]
- Ralph Kirby, Vartul Sangal, Nicholas P Tucker, Jolanta Zakrzewska-Czerwinska, Katarzyna Wierzbicka, Paul R Herron, Chun-Jong Chu, Govind Chandra, Ahmed H Fahal, Michael Goodfellow, and Paul A Hoskisson.
(2012) Draft Genome Sequence of the Human Pathogen Streptomyces somaliensis, a Significant Cause of Actinomycetoma.. JOURNAL OF BACTERIOLOGY 194, 3544-3545 [DOI: 10.1128/JB.00534-12]
- Sangal, V., Tucker, N. P., Burkovski, A. & Hoskisson, P. A. (2012) The Draft Genome Sequence of Corynebacterium diphtheriae bv. mitis NCTC 3529 Reveals Significant Diversity between the Primary Disease-Causing Biovars.. JOURNAL OF BACTERIOLOGY 194, 3269 [DOI: 10.1128/JB.00503-12]
- Edwards, R., Hunt, A. C., & Hoskisson, P. A. (2011) Recent cases of Non-toxigenic Corynebacterium diptheriae in Scotland: justification for continued surveillance.. Journal of Medical Microbiology 60, 561-562 [DOI: 10.1099/jmm.0.025643-0]
- Kirby, R. Herron, P. R. & Hoskisson, P. A. (2011) Analysis of developmental gene conservation in the Actinomycetales using DNA/DNA microarray comparisons.. Antonie van Leeuwenhoek 99, 159-177
- Katrin Adamczyk, Marco Candelaresi, Kirsty Robb, Andrea Gumiero, Martin A Walsh, Anthony W Parker, Paul A Hoskisson, Nicholas P Tucker, and Neil T Hunt. (2012) Measuring protein dynamics with ultrafast two-dimensional infrared spectroscopy.. MEASUREMENT SCIENCE & TECHNOLOGY 23, 062001 [DOI: 10.1088/0957-0233/23/6/062001] Published (review)
- Katrin Adamczyk, Marco Candelaresi, Rafal Kania, Kirsty Robb, César Bellota-Antón, Gregory M Greetham, Mark R Pollard, Michael Towrie, Anthony W Parker, Paul A Hoskisson, Nicholas P Tucker, and Neil T Hunt.
(2012) The effect of point mutation on the equilibrium structural fluctuations of ferric Myoglobin.. PHYSICAL CHEMISTRY CHEMICAL PHYSICS 14, 7411-7419 [DOI: 10.1039/c2cp23568d]
- Ralph Kirby, Vartul Sangal, Nicholas P Tucker, Jolanta Zakrzewska-Czerwinska, Katarzyna Wierzbicka, Paul R Herron, Chun-Jong Chu, Govind Chandra, Ahmed H Fahal, Michael Goodfellow, and Paul A Hoskisson.
(2012) Draft Genome Sequence of the Human Pathogen Streptomyces somaliensis, a Significant Cause of Actinomycetoma.. JOURNAL OF BACTERIOLOGY 194, 3544-3545 [DOI: 10.1128/JB.00534-12]
- Sangal, V., Tucker, N. P., Burkovski, A. & Hoskisson, P. A. (2012) The Draft Genome Sequence of Corynebacterium diphtheriae bv. mitis NCTC 3529 Reveals Significant Diversity between the Primary Disease-Causing Biovars.. JOURNAL OF BACTERIOLOGY 194, 3269 [DOI: 10.1128/JB.00503-12]
- Edwards, R., Hunt, A. C., & Hoskisson, P. A. (2011) Recent cases of Non-toxigenic Corynebacterium diptheriae in Scotland: justification for continued surveillance.. Journal of Medical Microbiology 60, 561-562 [DOI: 10.1099/jmm.0.025643-0]
- Kirby, R. Herron, P. R. & Hoskisson, P. A. (2011) Analysis of developmental gene conservation in the Actinomycetales using DNA/DNA microarray comparisons.. Antonie van Leeuwenhoek 99, 159-177
- Li,Q., Bai, Z., O'Donnell, A., Hoskisson P.A., Harvey, L.M. and McNeil, B. (2011) Oxidative stress in fungal fermentation processes: the roles of alternative respiration. BIOTECHNOLOGY LETTERS 33, 457-467 Published (review)
- Hoskisson PA, Trevors JT.
(2010) Shifting trends in pathogen dynamics on a changing planet. Antonie van Leeuwenhoek 98, 423-427
- Hoskisson, P. A. & Rigali, S. (2009) Variation in form and function: The Helix-turn-Helix regulators of the GntR superfamily. Advances in Applied Microbiology 69, 1-22
- Brown, R. P., Terrasa, B., Pérez-Mellado, V., Castro, J. A., Hoskisson, P. A., Picornell, A. & Ramon, M. M. (2008) Bayesian Estimation of Post-Messinian Divergence Times in Balearic Island Lizards. Molecular Phylogenetics and Evolution 48, 350-358 [DOI: 10.1016/j.ympev.2008.04.013]
- Hoskisson, Dr P., Rigali, S., Joris, B., Titgemeyer, F., Hiard, S., Mar?e, R., Colson, S., P. van Wezel, G., Wehenkel, L., (2007) PREDetector: A new tool to identify regulatory elements in bacterial genomes. Biochemical and Biophysical Research Communications 357, 861-864 [DOI: 10.1016/j.bbrc.2007.03.180 ]
- Hoskisson, Dr P., Smith, M.C.M., (2007) Hypervariation and phase variation in the bacteriophage ?resistome?. CURRENT OPINION IN MICROBIOLOGY 10, 396-400 [DOI: 10.1016/j.mib.2007.04.003 ]
- Hoskisson, Dr P., Brown, R.P., Welton, J., B?EZ, M., (2006) Geological history and within-island diversity: a debris avalanche and the Tenerife lizard Gallotia galloti. MOLECULAR ECOLOGY 15, 3631-3640 [DOI: 10.1111/j.1365-294X.2006.03048.x ]
- Hoskisson, Dr P., Hobbs, G., (2006) One size doesn't fit all. MICROBIOLOGY 152, 1891 [DOI: 10.1099/mic.0.29073-0 ]
- Hoskisson, Dr P., Hutchings, M.I., (2006) MtrAB?LpqB: a conserved three-component system in actinobacteria?. TRENDS IN MICROBIOLOGY 14, 444-449 [DOI: 10.1016/j.tim.2006.08.005 ]
- Hoskisson, Dr P., Khodakaramian, G., Gust, B., Lissenden, S., Moir, L., Chater, K.F., Smith, M.C.M., (2006) Expression of Cre recombinase during transient phage infection permits efficeient marker removal in Streptomyces. Nucleic Acids Research 34, e20 [DOI: 10.1093/nar/gnj019 ]
- Hoskisson, Dr P., Rigali, S., Fowler, K., Findley, K., Buttner, M.J., (2006) DevA, a GntR-like Transcriptional Regulator Required for Development in Streptomyces coelicolor. JOURNAL OF BACTERIOLOGY 188, 5014-5023 [DOI: 10.1128/JB.00307-06 ]
- Hoskisson, Dr P., Sharples, G.P., Hobbs, G., (2006) Differentiation and protease production in Micromonospora echinospora (ATCC 15837). Antonie van Leeuwenhoek 89, 191-195 [DOI: 10.1007/s10482-005-9001-6 ]
- Hoskisson, Dr P., Chandra, G., Buttner, M.J., Hutchings, M.I., (2004) Sensing and responding to diverse extracellular signals? Analysis of the sensor kinases and response regulators of Streptomyces coelicolor A3(2). MICROBIOLOGY 150, 2795-2806 [DOI: 10.1099/mic.0.27181-0 ]
- Hoskisson, Dr P., Rigali, S., Schlicht, M., Northaft, H., Merzbacher, M., Joris, B., Titgemeyer, F., (2004) Extending the classification of bacterial transcription factors beyond the helix?turn?helix motif as an alternative approach to discover new cis/trans relationships. Nucleic Acids Research 32, 3418-3426 [DOI: 10.1093/nar/gkh673 ]
view extended list
Group
Postgraduate students
Laura Clark : 'Elucidating the role of conserved gene clusters in actinomycetes' (started 2007)
Khanungkan Klanbut: 'The role of phospholipids in the growth and development of Streptomyces Coelicolor' (started 2009)
Leena Nieminen : 'Modelling metabolic switching in the differentiating bacterium streptomyces coelicolor' (started 2008)
Richard Alexander Reumerman: 'A novel systems approach to link primary and secondary metabolism during antibiotic production ' (started 2010)
Lewis Stewart: 'Transcriptional profiling of a pseudomonas aeruginosa - nematode infection model' (started 2010)
Charles Fredrik Webb: 'Phospholipid-protein interactions in streptomyces coelicolor' (started 2010)
