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Dr RuAngelie Edrada-Ebel

Lecturer

HW 304

ruangelie.edrada-ebel@strath.ac.uk

Tel : +44(0)141 548 5968 (Ext. 5968)


Profile

I was educated a pharmacist and received my PhD in Pharmaceutical Biology from the University of Würzburg in Germany, followed by a postdoctoral fellowship at the University of California at Santa Cruz in the laboratory of Professor Phil Crews. In 2001, I accepted a research fellowship with the group of Professor Peter Proksch at the University of Düsseldorf and I joined the University of Strathclyde as a lecturer in December 2008.  I am currently author of more than 80 publications and 2 patents.  My research focuses on natural products chemistry of macroorganisms and microorganisms from both the marine and the terrestrial habitat.  A new research focus of my group is the utilisation of the tools of metabolomics in the production of secondary metabolites in microbial symbionts from both marine and terrestrial sources.


Current Research

I have established research links and collaborations internally with the Fermentation Laboratory of Prof Brian McNeil as well as the Streptomyces group of Prof Iain Hunter and Dr Paul Herron. Working with the Fermentation Lab also gave way to a grant project on Real Time Flux Modelling in Biopharmaceutical Bioprocessing, jointly co-funded by the BBSRC and the EPSRC. Within the Pharmaceutical Analysis Group, there is a continuous collaboration with Dr David Watson on exploring the anti-trypanosomal activity of Propolis. In collaboration with members of the Drug Delivery group, Dr Christine Dufes, I was able to device an innovative analytical nmr methods to quantitatively detect polymer-drug conjugation in a tumour-targeted gene delivery system and Dr Chris van der Walle, I utilised nmr techniques to identify contaminants in the isolation of recombinant proteins from culture broth by co-precipitation with an amino acid carrier to form stable dry powders. On the national level, collaborative work on marine natural products and ecology have been established with the group of Prof Marcel Jaspars of the Marine Biodiscovery Centre, University of Aberdeen and Prof Douglas Neil of the Langoustine Laboratory, University of Glasgow. My recent collaboration with Prof Neil has launched a pilot project utilising the ScotMet Facility at Strathclyde to investigate the ecological implications of the production of secondary metabolites in Crustaceans for an alternative application of utilising the waste products of the by-catch.

International collaboration have been established with the groups of Prof Alan Dobson of the Environmental Research Institute, University College Cork and Prof Ute Hentschel of the Sponge Microbiology Group at the University of Wuerzburg to study the metabolomics of the production of secondary metabolites in marine microbial symbionts both from the cold waters of the Irish Sea and the warm water of the Red Sea.

Patents

Houssen WE, Lu Z, Edrada-Ebel RA, Chatzi C, Tucker SJ,  Sepčić K, Turk T,  Zovko A, Shen S, Mancini I, Scott RH, Jaspars M. DI-SUBSTITUTED PYRIDINIUM POLYMERS AND SYNTHESIS United Kingdom Patent Application No. 0918510.9 CODEN: WO/2010/086652. 2010, International Application No.: PCT/GB2010/050124

Bringmann, G.; Proksch, P.; Edrada, R. A.; Heubes, M.; Gunther, E.  „Isolation and synthesis of decalactones from Penicillium species and methods for making pharmaceuticals there from”. U.S. Pat. Appl. Publ., 8 pp. CODEN: USXXCO US  2003216354  A1  20031120.  2003, Application: US  2002-143596  20020509.

Teaching

MP408 (Formulation, Manufacture & Testing 1) Introduce basic NMR spectroscopy and mass spectrometry used in pharmaceutical analysis to qualitatively and quantitatively identify the drug impurity.
MP916 NMR spectroscopy workshop and Mass Spectrometry in Pharmaceutical Analysis
MP921 (Class Coordinator) Bioanalysis

"Real time matabolic flux modelling in biopharmaceutical bioprocessing"
BBSRC and EPSRC

"Investigating synergies between advanced bioprocess monitoring and production of valuable marine bioproducts."
BBSRC

"Metabolomics of microbial symbionts from Irish Sea Sponges"
Beaufort Marine Biodiversity Program, University College Cork

Publications

  • Bafor EE, Lim CV, Rowan EG, Edrada-Ebel R. (2013) The leaves of Ficus exasperata Vahl (Moraceae) generates uterine active chemical constituents.. Journal of Ethnopharmacology 145, 803-812 [DOI: 10.1016/j.jep.2012.12.020]

  • Aly AH, Debbab A, Clements C, Edrada-Ebel R, Orlikova B, Diederich M, Wray V, Lin W, Proksch P. (2011) NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum. BIOORGANIC & MEDICINAL CHEMISTRY 19, 414-421

  • Edrada-Ebel, RA (2011) Analgesics. In Pharmaceutical Chemistry. D.G.Watson ed. (2011), Elsevier, Edinburgh. Book Chapter , 269-296

  • H. Aldawsari, B. Sundara Raj, R. Edrada-Ebel, D.R. Blatchford, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex. Nanomedicine: Nanotechnology, Biology and Medicine 7 (5), 815-823 [DOI: 10.1016/j.nano.2011.01.016 ]

  • H. Aldawsari, R. Edrada-Ebel, D.R. Blatchford, R. J. Tate, L. Tetley, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex. Biomaterials 32, 5889-5899 [DOI: 10.1016/j.biomaterials.2011.04.079]

  • Aly AH1, Debbab A, Edrada-Ebel RA, Müller WEG, Kubbutat MHG, Wray V, Ebel R, and Proksch P (2010) Protein kinase inhibitors and other cytotoxic metabolites from the fungal endophyte Stemphylium botryosum isolated from Chenopodium album. Mycosphere 1, 153-162

view extended list

Group

MRes students

Adnan Alkhalil: 'Anti-trypanosomal Active Metabolites from Propolis' (started 2010)

Postgraduate students

Majed Mansour Madi Al Robaian: 'Preparation and analysis of novel tumour-targeted gene delivery systems for cancer therapy' (started 2011)

Mohammed Mofareh A Albratty: 'Metabonomic analysis of Drosophila mutants' (started 2009)

Sultan Saadi S Almutairi: 'Exploring the glycolytic metabolism of the blood stream forms of trypanosoma brucei using stable isotope labelling and mass spectrometry' (started 2011)

Enitome Evi Bafor: 'Isolation, identification and pharmacological evaluation of the actives of the leaf extracts of ficus exasperata vahl (moraceae)' (started 2010)

Nurkhalida Binti Kamal: 'Phytochemical study and bioactivities of Vitex Pinnata' (started 2009)

Tantima Kumlung: 'Improved routes to bioprocessing of biopharmaceuticals' (started 2007)

Alison Macfadyen: 'Determination the genetic basis of oxytetracycline productivity for streptomyces rimosus by the correlation of genomic and metabolomic data' (started 2010)

Ahmed Fares Tawfike: 'Chemical dereplication studies of endophytic and endozoic metabolites of both terrestrial and marine sources by using metabolomics as a tool in the se' (started 2010)

Christina Victoria Viegelmann: 'Metabolomics as a tool in the identification and production of new marine derived antibiotics from the coastlines of the British isles' (started 2010)

Collaborators

Prof. Ute Hentschel, University Of Wuerzburg

Dr Jonathan Kennedy, University College Cork

Prof. Alan Dobson, University College Cork

Prof. Marcel Jaspars, University Of Aberdeen

Prof. Peter Proksch, University Of Duesseldorf

Prof Douglas Neil, University Of Glasgow





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