"Real time matabolic flux modelling in biopharmaceutical bioprocessing"
BBSRC and EPSRC

"Investigating synergies between advanced bioprocess monitoring and production of valuable marine bioproducts."
BBSRC

"Metabolomics of microbial symbionts from Irish Sea Sponges"
Beaufort Marine Biodiversity Program, University College Cork

Publications

• Bafor EE, Lim CV, Rowan EG, Edrada-Ebel R. (2013) The leaves of Ficus exasperata Vahl (Moraceae) generates uterine active chemical constituents.. Journal of Ethnopharmacology 145, 803-812 [DOI: 10.1016/j.jep.2012.12.020]
  
  
• Aldawsari, HM, Edrada-Ebel, R, Blatchford, D, Tate, RJ, Tetley, L & Dufès, C (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex.. Biomaterials 32, 5889-5899 [DOI: 10.1016/j.biomaterials.2011.04.079]
  
  
• Aldawsari, HM, Sundara Raj, B, Edrada-Ebel, R, Blatchford, D, Tate, RJ, Tetley, L & Dufès, C (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex.. Nanomedicine: Nanotechnology, Biology and Medicine 7, 815-823 [DOI: 10.1016/j.nano.2011.01.016]
  
  
• Aly AH, Debbab A, Clements C, Edrada-Ebel R, Orlikova B, Diederich M, Wray V, Lin W, Proksch P. (2011) NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum. BIOORGANIC & MEDICINAL CHEMISTRY 19, 414-421
  
  
• Edrada-Ebel, RA (2011) Analgesics. In Pharmaceutical Chemistry. D.G.Watson ed. (2011), Elsevier, Edinburgh. Book Chapter , 269-296
  
  
• H. Aldawsari, B. Sundara Raj, R. Edrada-Ebel, D.R. Blatchford, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex. Nanomedicine: Nanotechnology, Biology and Medicine 7 (5), 815-823 [DOI: 10.1016/j.nano.2011.01.016 ]
  
  

• Bafor EE, Lim CV, Rowan EG, Edrada-Ebel R. (2013) The leaves of Ficus exasperata Vahl (Moraceae) generates uterine active chemical constituents.. Journal of Ethnopharmacology 145, 803-812 [DOI: 10.1016/j.jep.2012.12.020]
  
  
• Aldawsari, HM, Edrada-Ebel, R, Blatchford, D, Tate, RJ, Tetley, L & Dufès, C (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex.. Biomaterials 32, 5889-5899 [DOI: 10.1016/j.biomaterials.2011.04.079]
  
  
• Aldawsari, HM, Sundara Raj, B, Edrada-Ebel, R, Blatchford, D, Tate, RJ, Tetley, L & Dufès, C (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex.. Nanomedicine: Nanotechnology, Biology and Medicine 7, 815-823 [DOI: 10.1016/j.nano.2011.01.016]
  
  
• Aly AH, Debbab A, Clements C, Edrada-Ebel R, Orlikova B, Diederich M, Wray V, Lin W, Proksch P. (2011) NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum. BIOORGANIC & MEDICINAL CHEMISTRY 19, 414-421
  
  
• Edrada-Ebel, RA (2011) Analgesics. In Pharmaceutical Chemistry. D.G.Watson ed. (2011), Elsevier, Edinburgh. Book Chapter , 269-296
  
  
• H. Aldawsari, B. Sundara Raj, R. Edrada-Ebel, D.R. Blatchford, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex. Nanomedicine: Nanotechnology, Biology and Medicine 7 (5), 815-823 [DOI: 10.1016/j.nano.2011.01.016 ]
  
  
• H. Aldawsari, R. Edrada-Ebel, D.R. Blatchford, R. J. Tate, L. Tetley, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex. Biomaterials 32, 5889-5899 [DOI: 10.1016/j.biomaterials.2011.04.079]
  
  
• Aldawsari, HM, Sundara Raj, B, Edrada-Ebel, R, Blatchford, D, Tate, RJ & Dufès, C. (2010) Enhanced transfection efficacy of polyethylenimine by surface modification with arginine, lysine, and leucine.. Controlled Release Society Newsletter 27, 12-14
  
  
• Aly AH1, Debbab A, Edrada-Ebel RA, Müller WEG, Kubbutat MHG, Wray V, Ebel R, and Proksch P (2010) Protein kinase inhibitors and other cytotoxic metabolites from the fungal endophyte Stemphylium botryosum isolated from Chenopodium album. Mycosphere 1, 153-162
  
  
• H. Aldawsari, B. Sundara Raj, R. Edrada-Ebel, D. R. Blatchford, R. J. Tate, C. Dufès (2010) Enhanced Transfection Efficacy of Polyethylenimine by Surface Modification with Arginine, Lysine, and Leucine. Controlled Release Society Newsletter 27, 10-12
  
  
• Hertiani T, EDRADA-EBEL RA , Ortlepp S, van Soest RWM, de Voogd NJ, Wray V, Hentschel U, Kozytska S, Müller WEG, PROKSCH P (2010) From anti-fouling to biofilm inhibition: New cytotoxic secondary metabolites from two Indonesian Agelas sponges. BIOORGANIC & MEDICINAL CHEMISTRY 18, 1297–1311
  
  
• Houssen WE, Lu Z, Edrada-Ebel RA, Chatzi C, Tucker SJ, Sepčić K, Turk T, Zovko A, Shen S, Mancini I, Scott RH, Jaspars M. (2010) Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins. Journal of Chemical Biology 3, 113-125
  
  
• Ibrahim SR, Min CC, Teuscher F, Ebel R, Kakoschke C, Lin W, Wray V, Edrada-Ebel R, Proksch P. (2010) Callyaerins A–F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa. BIOORGANIC & MEDICINAL CHEMISTRY 18, 4947-4956
  
  
• Koppu, S, Oh, YJ, Edrada-Ebel, R, Blatchford, DR, Tetley, L, Tate, RJ & Dufès, C (2010) Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA.. Journal of Controlled Release 143, 215-221 [DOI: 10.1016/j.jconrel.2009.11.015]
  
  
• Moore BD, Deere J, Edrada-Ebel R, Ingram A, van der Walle CF. (2010) Isolation of recombinant proteins from culture broth by co-precipitation with an amino acid carrier to form stable dry powders. BIOTECHNOLOGY AND BIOENGINEERING 106, 764-773 [DOI: 10.1002/bit.22730]
  
  
• Okoye FBC, Osadebe PO, Proksch P, Edrada-Ebel RA, Nworu CS, ESIMONE SO (2010) Anti-inflammatory and Membrane-stabilizing Stigmastane Steroids from Alchornea floribunda Leaves. Planta Medica 76, 172-177
  
  
• S. Koppu, Y.J. Oh, R. Edrada-Ebel, D.R. Blatchford, L. Tetley, R.J. Tate, C. Dufès (2010) Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA. Journal of Controlled Release 143, 215-221 [DOI: 10.1016/j.jconrel.2009.11.015]
  
  
• Aly AH, Debbab A, Edrada-Ebel R, Wray V, Müller WE, Lin W, Ebel R, Proksch P. (2009) A new tetrahydrofuran derivative from the endophytic fungus Chaetomium sp. isolated from Otanthus maritimus. Zeitschrift fuer Naturforschung, C: Journal of Biosciences 64, 350-354
  
  
• Debbab A, Aly AH, Edrada-Ebel RA, Mueller WEG, Mosaddak M, Hakiki A, Ebel R, Proksch P. (2009) Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. Biotechnology, Agronomy, Society and Environment (BASE) 13, 229-234
  
  
• Debbab, Adbessamad ; Aly, Amal H. ; Edrada-Ebel, RuAngelie ; Wray, Victor ; Muller, Werner E.G. ; Totzke, Frank ; Zirrgiebel, Ute ; Schachtele, Christoph ; Kubbutat, Michael H.G. ; Lin, Wenhan ; Mosaddak, Mahjouba ; Hakikj, Adbelhak ; Proksch, Peter ; Ebe (2009) Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum isolated from Mentha pulegium. Journal of Natural Products 72, 626-631 [DOI: 10.1021/np8004997]
  
  
• Ebada SS, Edrada-Ebel RA, de Voogd NJ, Wray V, Proksch P. (2009) Dibromopyrrole alkaloids from the Marine Sponge Acanthostylotella sp.. Natural Product Communications 4, 47-52
  
  
• Ebada SS, Edrada-Ebel RA, Lin W, Proksch P. (2009) Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates. Nature Protocols 3, 1820-1831 [DOI: 10.1038/nprot.2008.182]
  
  
• Kjer, J; Wray, V; Edrada-Ebel, RA; Ebel, R; Pretsch, A; Lin, W; PROKSCH, P (2009) Xanalteric Acids I and II and Related Phenolic Compounds from an Endophytic Alternaria sp. Isolated from the Mangrove Plant Sonneratia alba. Journal of Natural Products 72, 2053-2057
  
  
• L. Zheng, D. G. Watson, B. F. Johnston, R. L. Clark, R. Edrada-Ebel and W. Elseheri (2009) A chemometric study of chromatograms of tea extracts by correlation optimization warping in conjunction with PCA, support vector machines and random forest data modeling. Analytica Chimica Acta 642, 257-265 [DOI: 10.1016/j.aca.2008.12.015]
  
  
• Liu H, Edrada-Ebel RA, Ebel R, Wang Y, Schulz B, Draeger S, Mueller WEG, Wray V, Lin W, Proksch P. (2009) Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. Journal of Natural Products 72, 1585–1588 [DOI: 10.1021/np900220r]
  
  
• N. J. Wheate, G. M. Abbott, R. J. Tate, C. J. Clements, R. Edrada-Ebel and B. F. Johnston (2009) Side-on binding of p-sulphonatocalix 4 arene to the dinuclear platinum complex trans- {PtCl(NH3)(2)}(2)mu-dpzm (2+) and its implications for anticancer drug delivery. Journal of Inorganic Biochemistry 103, 448-454 [DOI: 10.1016/j.jinorgbio.2008.12.011]
  
  
• Wang Y, Edrada-Ebel RA, Tsevegsuren N, Sendker J, Braun M, Wray V, Lin W, Proksch P. (2009) Dihydrostilbene derivatives from the Mongolian medicinal plant Scorzonera radiata. Journal of Natural Products 72, 671-675 [DOI: 10.1021/np800782f ]
  
  
• Wheate, NJ, Abbott, GM, Tate, RJ, Clements, CJ, Edrada-Ebel, R & Johnston, BF. (2009) 'Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH3)2}2μ-dpzm]2+ and its implications for anticancer drug delivery.. Journal of Inorganic Biochemistry 103, 448-454 [DOI: 10.1016/j.jinorgbio.2008.12.011]
  
  
• Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Kampkötter A, Edrada-Ebel RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MH, Proksch P. (2009) Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Molecular Nutrition & Food Research 53, 431-440 [DOI: 10.1002/mnfr.200700428]
  
  
• Xu J, Kjer J, Sendker J, Wray V, Guan H, Edrada RA, Lin W, Wu J, Proksch P. (2009) Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. Journal of Natural Products 72, 662-665 [DOI: 10.1021/np800748u]
  
  
• Xu J, Kjer J, Sendker J, Wray V, Guan H, Edrada RA,Mueller WEG, Bayer M, Lin W, Wu J, Proksch P (2009) Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. BIOORGANIC & MEDICINAL CHEMISTRY 17, 7362-7367 [DOI: 10.1016/j.bmc.2009.08.031]
  
  
• Aly AH, Edrada-Ebel R, Indriani ID, Wray V, Müller WEG, Totzke F, Zirrgiebel U, Schächtele C, Kubbutat MH, Lin WH, Proksch P, Ebel R. (2008) Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of Natural Products 71, 972-980 [DOI: 10.1021/np070447m]
  
  
• Aly AH, Edrada-Ebel RA, Wray V, Müller WEG, Kozytska S, Hentschel U, Proksch P, Ebel R. (2008) Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides. Phytochemistry 69, 1716-1725 [DOI: 10.1016/j.phytochem.2008.02.013]
  
  
• Ashour M, Edrada-Ebel RA, Ebel R, Wray V, van Soest RWM, Proksch P. (2008) New purine derivatives from the marine sponge Petrosia nigricans. Natural Product Communications 3, 1889-1994
  
  
• Hertiani T, Edrada RA, Kubbutat M, van Soest RWM, Proksch P. (2008) Protein kinase inhibitors from Indonesian sponge Axynissa sp. Majalah Farmasi Indonesia 19, 78-85
  
  
• Hertiani T, Edrada RA, van Soest RWM, Sudarsono, Proksch P. (2008) Isolation and structure identification of new alkaloids from the sponge Rhabdastrella rowi. Majalah Farmasi Indonesia 19, 128-136
  
  
• Ibrahim SR, Ebel R, Wray V, Müller WE, Edrada-Ebel R, Proksch P. (2008) Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa. Journal of Natural Products 71, 1358-1364 [DOI: 10.1021/np800102u]
  
  
• Ibrahim SRM, Edrada-Ebel RA, Mohamed GA, Youssef DTA, Wray V, Proksch P. (2008) Callyaerin G, a new cytotoxic cyclic peptide from the marine sponge allyspongia aerizusa. ARKIVOC 12, 164-171
  
  
• Kumar S, Kaushik N, Edrada-Ebel RA, Ebel R, Proksch P (2008) Endophytic Fungi for Pest and Disease Management. Ciancio A, Mukerji KG (Eds.) Integrated Management of Diseases Caused by Fungi, Phytoplasma and Bacteria. Springer-Verlag, Berlin.. Book Chapter , 365-387
  
  
• Proksch, Peter; Ebel, Rainer; Edrada, RuAngelie; Riebe, Frank; Liu, Hongbing; Diesel, Arnulf; Bayer, Mirko; Li, Xiang; Han Lin, Wen; Grebenyuk, Vladislav; Müller, Werner E.G.; Draeger, Siegfried; Zuccaro, Alga; Schulz, Barbara (2008) Sponge-associated fungi and their bioactive compounds - the Suberites case. Botanica Marina 51, 209-218 [DOI: 10.1515/BOT.2008.014 ]
  
  
• Sowemimo AA, Edrada-Ebel RA, Ebel R, Proksch P, Omobuwajo OR, Adesanya A. (2008) Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia.. Natural Product Communications 3, 1217-1222
  
  
• Vasilev N, Ebel R, Edrada RA, Fuss E, Alfermann AW, Ionkova I, Petrova A, Repplinger M, Schmidt TJ. (2008) Metabolic Profiling of Lignan Variability in Linum species of Section Syllinum native to Bulgaria. Planta Medica 74, 273-280 [DOI: 10.1055/s-2008-1034298]
  
  

view extended list

Group

MRes students

Adnan Alkhalil

Postgraduate students

Majed Mansour Madi Al Robaian: 'Preparation and analysis of novel tumour-targeted gene delivery systems for cancer therapy' (started 2011)

Mohammed Mofareh A Albratty: 'Metabonomic analysis of Drosophila mutants' (started 2009)

Sultan Saadi S Almutairi: 'Exploring the glycolytic metabolism of the blood stream forms of trypanosoma brucei using stable isotope labelling and mass spectrometry' (started 2011)

Enitome Evi Bafor: 'Isolation, identification and pharmacological evaluation of the actives of the leaf extracts of ficus exasperata vahl (moraceae)' (started 2010)

Nurkhalida Binti Kamal: 'Phytochemical study and bioactivities of Vitex Pinnata' (started 2009)

Tantima Kumlung: 'Improved routes to bioprocessing of biopharmaceuticals' (started 2007)

Alison Macfadyen: 'Determination the genetic basis of oxytetracycline productivity for streptomyces rimosus by the correlation of genomic and metabolomic data' (started 2010)

Ahmed Fares Tawfike: 'Chemical dereplication studies of endophytic and endozoic metabolites of both terrestrial and marine sources by using metabolomics as a tool in the se' (started 2010)

Christina Victoria Viegelmann: 'Metabolomics as a tool in the identification and production of new marine derived antibiotics from the coastlines of the British isles' (started 2010)

Collaborators

Prof. Ute Hentschel, University Of Wuerzburg

Dr Jonathan Kennedy, University College Cork

Prof. Alan Dobson, University College Cork

Prof. Marcel Jaspars, University Of Aberdeen

Prof. Peter Proksch, University Of Duesseldorf

Prof Douglas Neil, University Of Glasgow