I was educated a pharmacist and received my PhD in Pharmaceutical Biology from the University of Würzburg in Germany, followed by a postdoctoral fellowship at the University of California at Santa Cruz in the laboratory of Professor Phil Crews. In 2001, I accepted a research fellowship with the group of Professor Peter Proksch at the University of Düsseldorf and I joined the University of Strathclyde as a lecturer in December 2008. I am currently author of more than 80 publications and 2 patents. My research focuses on natural products chemistry of macroorganisms and microorganisms from both the marine and the terrestrial habitat. A new research focus of my group is the utilisation of the tools of metabolomics in the production of secondary metabolites in microbial symbionts from both marine and terrestrial sources.
Current Research
I have established research links and collaborations internally with the Fermentation Laboratory of Prof Brian McNeil as well as the Streptomyces group of Prof Iain Hunter and Dr Paul Herron. Working with the Fermentation Lab also gave way to a grant project on Real Time Flux Modelling in Biopharmaceutical Bioprocessing, jointly co-funded by the BBSRC and the EPSRC. Within the Pharmaceutical Analysis Group, there is a continuous collaboration with Dr David Watson on exploring the anti-trypanosomal activity of Propolis. In collaboration with members of the Drug Delivery group, Dr Christine Dufes, I was able to device an innovative analytical nmr methods to quantitatively detect polymer-drug conjugation in a tumour-targeted gene delivery system and Dr Chris van der Walle, I utilised nmr techniques to identify contaminants in the isolation of recombinant proteins from culture broth by co-precipitation with an amino acid carrier to form stable dry powders. On the national level, collaborative work on marine natural products and ecology have been established with the group of Prof Marcel Jaspars of the Marine Biodiscovery Centre, University of Aberdeen and Prof Douglas Neil of the Langoustine Laboratory, University of Glasgow. My recent collaboration with Prof Neil has launched a pilot project utilising the ScotMet Facility at Strathclyde to investigate the ecological implications of the production of secondary metabolites in Crustaceans for an alternative application of utilising the waste products of the by-catch.
International collaboration have been established with the groups of Prof Alan Dobson of the Environmental Research Institute, University College Cork and Prof Ute Hentschel of the Sponge Microbiology Group at the University of Wuerzburg to study the metabolomics of the production of secondary metabolites in marine microbial symbionts both from the cold waters of the Irish Sea and the warm water of the Red Sea.
Patents
Houssen WE, Lu Z, Edrada-Ebel RA, Chatzi C, Tucker SJ, Sepčić K, Turk T, Zovko A, Shen S, Mancini I, Scott RH, Jaspars M. DI-SUBSTITUTED PYRIDINIUM POLYMERS AND SYNTHESIS United Kingdom Patent Application No. 0918510.9 CODEN: WO/2010/086652. 2010, International Application No.: PCT/GB2010/050124
Bringmann, G.; Proksch, P.; Edrada, R. A.; Heubes, M.; Gunther, E. „Isolation and synthesis of decalactones from Penicillium species and methods for making pharmaceuticals there from”. U.S. Pat. Appl. Publ., 8 pp. CODEN: USXXCO US 2003216354 A1 20031120. 2003, Application: US 2002-143596 20020509.
Teaching
MP408 (Formulation, Manufacture & Testing 1) Introduce basic NMR spectroscopy and mass spectrometry used in pharmaceutical analysis to qualitatively and quantitatively identify the drug impurity. MP916 NMR spectroscopy workshop and Mass Spectrometry in Pharmaceutical Analysis MP921 (Class Coordinator) Bioanalysis
"Real time matabolic flux modelling in biopharmaceutical bioprocessing" BBSRC and EPSRC
"Investigating synergies between advanced bioprocess monitoring and production of valuable marine bioproducts." BBSRC
"Metabolomics of microbial symbionts from Irish Sea Sponges" Beaufort Marine Biodiversity Program, University College Cork
Publications
H. Aldawsari, R. Edrada-Ebel, D.R. Blatchford, R. J. Tate, L. Tetley, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex. Biomaterials32, 5889-5899 [DOI: 10.1016/j.biomaterials.2011.04.079]
S. Koppu, Y.J. Oh, R. Edrada-Ebel, D.R. Blatchford, L. Tetley, R.J. Tate, C. Dufès (2010) Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA. Journal of Controlled Release143, 215-221 [DOI: 10.1016/j.jconrel.2009.11.015]
H. Aldawsari, B. Sundara Raj, R. Edrada-Ebel, D.R. Blatchford, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex. Nanomedicine: Nanotechnology, Biology and Medicine7 (5), 815-823 [DOI: 10.1016/j.nano.2011.01.016 ]
Ebada SS, Edrada-Ebel RA, Lin W, Proksch P. (2009) Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates. Nature Protocols3, 1820-1831 [DOI: 10.1038/nprot.2008.182]
Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Kampkötter A, Edrada-Ebel RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MH, Proksch P. (2009) Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Molecular Nutrition & Food Research53, 431-440 [DOI: 10.1002/mnfr.200700428]
L. Zheng, D. G. Watson, B. F. Johnston, R. L. Clark, R. Edrada-Ebel and W. Elseheri (2009) A chemometric study of chromatograms of tea extracts by correlation optimization warping in conjunction with PCA, support vector machines and random forest data modeling. Analytica Chimica Acta642, 257-265 [DOI: 10.1016/j.aca.2008.12.015]
H. Aldawsari, R. Edrada-Ebel, D.R. Blatchford, R. J. Tate, L. Tetley, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex. Biomaterials32, 5889-5899 [DOI: 10.1016/j.biomaterials.2011.04.079]
S. Koppu, Y.J. Oh, R. Edrada-Ebel, D.R. Blatchford, L. Tetley, R.J. Tate, C. Dufès (2010) Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA. Journal of Controlled Release143, 215-221 [DOI: 10.1016/j.jconrel.2009.11.015]
H. Aldawsari, B. Sundara Raj, R. Edrada-Ebel, D.R. Blatchford, C. Dufès (2011) Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex. Nanomedicine: Nanotechnology, Biology and Medicine7 (5), 815-823 [DOI: 10.1016/j.nano.2011.01.016 ]
Ebada SS, Edrada-Ebel RA, Lin W, Proksch P. (2009) Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates. Nature Protocols3, 1820-1831 [DOI: 10.1038/nprot.2008.182]
Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Kampkötter A, Edrada-Ebel RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MH, Proksch P. (2009) Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Molecular Nutrition & Food Research53, 431-440 [DOI: 10.1002/mnfr.200700428]
L. Zheng, D. G. Watson, B. F. Johnston, R. L. Clark, R. Edrada-Ebel and W. Elseheri (2009) A chemometric study of chromatograms of tea extracts by correlation optimization warping in conjunction with PCA, support vector machines and random forest data modeling. Analytica Chimica Acta642, 257-265 [DOI: 10.1016/j.aca.2008.12.015]
N. J. Wheate, G. M. Abbott, R. J. Tate, C. J. Clements, R. Edrada-Ebel and B. F. Johnston (2009) Side-on binding of p-sulphonatocalix 4 arene to the dinuclear platinum complex trans- {PtCl(NH3)(2)}(2)mu-dpzm (2+) and its implications for anticancer drug delivery. Journal of Inorganic Biochemistry 103, 448-454 [DOI: 10.1016/j.jinorgbio.2008.12.011]
Aly AH, Debbab A, Clements C, Edrada-Ebel R, Orlikova B, Diederich M, Wray V, Lin W, Proksch P. (2011) NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum. BIOORGANIC & MEDICINAL CHEMISTRY19, 414-421
Hertiani T, EDRADA-EBEL RA , Ortlepp S, van Soest RWM, de Voogd NJ, Wray V, Hentschel U, Kozytska S, Müller WEG, PROKSCH P (2010) From anti-fouling to biofilm inhibition: New cytotoxic secondary metabolites from two Indonesian Agelas sponges. BIOORGANIC & MEDICINAL CHEMISTRY18, 1297–1311
Ibrahim SR, Min CC, Teuscher F, Ebel R, Kakoschke C, Lin W, Wray V, Edrada-Ebel R, Proksch P.
(2010) Callyaerins A–F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa. BIOORGANIC & MEDICINAL CHEMISTRY18, 4947-4956
Xu J, Kjer J, Sendker J, Wray V, Guan H, Edrada RA,Mueller WEG, Bayer M, Lin W, Wu J, Proksch P (2009) Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. BIOORGANIC & MEDICINAL CHEMISTRY17, 7362-7367 [DOI: 10.1016/j.bmc.2009.08.031]
Aly AH, Edrada-Ebel RA, Wray V, Müller WEG, Kozytska S, Hentschel U, Proksch P, Ebel R. (2008) Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides. Phytochemistry69, 1716-1725 [DOI: 10.1016/j.phytochem.2008.02.013]
Moore BD, Deere J, Edrada-Ebel R, Ingram A, van der Walle CF.
(2010) Isolation of recombinant proteins from culture broth by co-precipitation with an amino acid carrier to form stable dry powders. BIOTECHNOLOGY AND BIOENGINEERING106, 764-773 [DOI: 10.1002/bit.22730]
Debbab, Adbessamad ; Aly, Amal H. ; Edrada-Ebel, RuAngelie ; Wray, Victor ; Muller, Werner E.G. ; Totzke, Frank ; Zirrgiebel, Ute ; Schachtele, Christoph ; Kubbutat, Michael H.G. ; Lin, Wenhan ; Mosaddak, Mahjouba ; Hakikj, Adbelhak ; Proksch, Peter ; Ebe (2009) Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum isolated from Mentha pulegium. Journal of Natural Products72, 626-631 [DOI: 10.1021/np8004997]
Kjer, J; Wray, V; Edrada-Ebel, RA; Ebel, R; Pretsch, A; Lin, W; PROKSCH, P (2009) Xanalteric Acids I and II and Related Phenolic Compounds from an Endophytic Alternaria sp. Isolated from the Mangrove Plant Sonneratia alba. Journal of Natural Products72, 2053-2057
Liu H, Edrada-Ebel RA, Ebel R, Wang Y, Schulz B, Draeger S, Mueller WEG, Wray V, Lin W, Proksch P. (2009) Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. Journal of Natural Products72, 1585–1588 [DOI: 10.1021/np900220r]
Wang Y, Edrada-Ebel RA, Tsevegsuren N, Sendker J, Braun M, Wray V, Lin W, Proksch P. (2009) Dihydrostilbene derivatives from the Mongolian medicinal plant Scorzonera radiata. Journal of Natural Products72, 671-675 [DOI: 10.1021/np800782f ]
Xu J, Kjer J, Sendker J, Wray V, Guan H, Edrada RA, Lin W, Wu J, Proksch P. (2009) Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. Journal of Natural Products72, 662-665 [DOI: 10.1021/np800748u]
Aly AH, Edrada-Ebel R, Indriani ID, Wray V, Müller WEG, Totzke F, Zirrgiebel U, Schächtele C, Kubbutat MH, Lin WH, Proksch P, Ebel R. (2008) Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of Natural Products71, 972-980 [DOI: 10.1021/np070447m]
Ibrahim SR, Ebel R, Wray V, Müller WE, Edrada-Ebel R, Proksch P. (2008) Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa. Journal of Natural Products71, 1358-1364 [DOI: 10.1021/np800102u]
Okoye FBC, Osadebe PO, Proksch P, Edrada-Ebel RA, Nworu CS, ESIMONE SO (2010) Anti-inflammatory and Membrane-stabilizing Stigmastane Steroids from Alchornea floribunda Leaves. Planta Medica76, 172-177
Vasilev N, Ebel R, Edrada RA, Fuss E, Alfermann AW, Ionkova I, Petrova A, Repplinger M, Schmidt TJ. (2008) Metabolic Profiling of Lignan Variability in Linum species of Section Syllinum native to Bulgaria. Planta Medica74, 273-280 [DOI: 10.1055/s-2008-1034298]
Ibrahim SRM, Edrada-Ebel RA, Mohamed GA, Youssef DTA, Wray V, Proksch P. (2008) Callyaerin G, a new cytotoxic cyclic peptide from the marine sponge allyspongia aerizusa. ARKIVOC12, 164-171
Proksch P, Ebel R, Edrada RA, Riebe F, Liu H, Diesel A, Bayer M, Li X, Lin, WH, Grebenyuk V, Müller, WEG, Draeger, S, Zuccaro A, Schulz B. (2008) Sponge-associated fungi and their bioactive compounds – the Suberites case. Botanica Marina51, 209-218
Proksch, Peter; Ebel, Rainer; Edrada, RuAngelie; Riebe, Frank; Liu, Hongbing; Diesel, Arnulf; Bayer, Mirko; Li, Xiang; Han Lin, Wen; Grebenyuk, Vladislav; Müller, Werner E.G.; Draeger, Siegfried; Zuccaro, Alga; Schulz, Barbara
(2008) Sponge-associated fungi and their bioactive compounds - the Suberites case. Botanica Marina51, 209-218 [DOI: 10.1515/BOT.2008.014 ]
Aly AH, Debbab A, Edrada-Ebel R, Wray V, Müller WE, Lin W, Ebel R, Proksch P.
(2009) A new tetrahydrofuran derivative from the endophytic fungus Chaetomium sp. isolated from Otanthus maritimus. Zeitschrift fuer Naturforschung, C: Journal of Biosciences64, 350-354
Ebada SS, Edrada-Ebel RA, de Voogd NJ, Wray V, Proksch P. (2009) Dibromopyrrole alkaloids from the Marine Sponge Acanthostylotella sp.. Natural Product Communications4, 47-52
Ashour M, Edrada-Ebel RA, Ebel R, Wray V, van Soest RWM, Proksch P. (2008) New purine derivatives from the marine sponge Petrosia nigricans. Natural Product Communications3, 1889-1994
Sowemimo AA, Edrada-Ebel RA, Ebel R, Proksch P, Omobuwajo OR, Adesanya A. (2008) Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia.. Natural Product Communications3, 1217-1222
Edrada-Ebel, RA (2011) Analgesics. In Pharmaceutical Chemistry. D.G.Watson ed. (2011), Elsevier, Edinburgh. Book Chapter , 269-296
Aly AH1, Debbab A, Edrada-Ebel RA, Müller WEG, Kubbutat MHG, Wray V, Ebel R,
and Proksch P (2010) Protein kinase inhibitors and other cytotoxic metabolites from the fungal endophyte Stemphylium botryosum isolated from Chenopodium album. Mycosphere1, 153-162
H. Aldawsari, B. Sundara Raj, R. Edrada-Ebel, D. R. Blatchford, R. J. Tate, C. Dufès (2010) Enhanced Transfection Efficacy of Polyethylenimine by Surface Modification with Arginine, Lysine, and Leucine. Controlled Release Society Newsletter27, 10-12
Houssen WE, Lu Z, Edrada-Ebel RA, Chatzi C, Tucker SJ, Sepčić K, Turk T, Zovko A, Shen S, Mancini I, Scott RH, Jaspars M. (2010) Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins. Journal of Chemical Biology3, 113-125
Debbab A, Aly AH, Edrada-Ebel RA, Mueller WEG, Mosaddak M, Hakiki A, Ebel R, Proksch P. (2009) Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. Biotechnology, Agronomy, Society and Environment (BASE)13, 229-234
Hertiani T, Edrada RA, Kubbutat M, van Soest RWM, Proksch P. (2008) Protein kinase inhibitors from Indonesian sponge Axynissa sp. Majalah Farmasi Indonesia19, 78-85
Hertiani T, Edrada RA, van Soest RWM, Sudarsono, Proksch P. (2008) Isolation and structure identification of new alkaloids from the sponge Rhabdastrella rowi. Majalah Farmasi Indonesia19, 128-136
Kumar S, Kaushik N, Edrada-Ebel RA, Ebel R, Proksch P (2008) Endophytic Fungi for Pest and Disease Management. Ciancio A, Mukerji KG (Eds.) Integrated Management of Diseases Caused by Fungi, Phytoplasma and Bacteria. Springer-Verlag, Berlin.. Book Chapter , 365-387
Majed Mansour Madi Al Robaian: 'Preparation and analysis of novel tumour-targeted gene delivery systems for cancer therapy' (started 2011)
Mohammed Mofareh A Albratty: 'Metabonomic analysis of Drosophila mutants' (started 2009)
Sultan Saadi S Almutairi: 'Exploring the glycolytic metabolism of the blood stream forms of trypanosoma brucei using stable isotope labelling and mass spectrometry' (started 2011)
Enitome Evi Bafor: 'Isolation, identification and pharmacological evaluation of the actives of the leaf extracts of ficus exasperata vahl (moraceae)' (started 2010)
Nurkhalida Binti Kamal: 'Phytochemical study and bioactivities of Vitex Pinnata' (started 2009)
Tantima Kumlung: 'Improved routes to bioprocessing of biopharmaceuticals' (started 2007)
Alison Macfadyen: 'Determination the genetic basis of oxytetracycline productivity for streptomyces rimosus by the correlation of genomic and metabolomic data' (started 2010)
Ahmed Fares Tawfike: 'Chemical dereplication studies of endophytic and endozoic metabolites of both terrestrial and marine sources by using metabolomics as a tool in the se' (started 2010)
Christina Victoria Viegelmann: 'Metabolomics as a tool in the identification and production of new marine derived antibiotics from the coastlines of the British isles' (started 2010)
