Dr RuAngelie Edrada-Ebel
Tel : +44(0)141 548 5968 (Ext. 5968)
I was educated a pharmacist and received my PhD in Pharmaceutical Biology from the University of Würzburg in Germany, followed by a postdoctoral fellowship at the University of California at Santa Cruz in the laboratory of Professor Phil Crews. In 2001, I accepted a research fellowship with the group of Professor Peter Proksch at the University of Düsseldorf and I joined the University of Strathclyde as a lecturer in December 2008. I am currently author of more than 80 publications and 2 patents. My research focuses on natural products chemistry of macroorganisms and microorganisms from both the marine and the terrestrial habitat. A new research focus of my group is the utilisation of the tools of metabolomics in the production of secondary metabolites in microbial symbionts from both marine and terrestrial sources.
I have established research links and collaborations internally with the Fermentation Laboratory of Prof Brian McNeil as well as the Streptomyces group of Prof Iain Hunter and Dr Paul Herron. Working with the Fermentation Lab also gave way to a grant project on Real Time Flux Modelling in Biopharmaceutical Bioprocessing, jointly co-funded by the BBSRC and the EPSRC. Within the Pharmaceutical Analysis Group, there is a continuous collaboration with Dr David Watson on exploring the anti-trypanosomal activity of Propolis. In collaboration with members of the Drug Delivery group, Dr Christine Dufes, I was able to device an innovative analytical nmr methods to quantitatively detect polymer-drug conjugation in a tumour-targeted gene delivery system and Dr Chris van der Walle, I utilised nmr techniques to identify contaminants in the isolation of recombinant proteins from culture broth by co-precipitation with an amino acid carrier to form stable dry powders. On the national level, collaborative work on marine natural products and ecology have been established with the group of Prof Marcel Jaspars of the Marine Biodiscovery Centre, University of Aberdeen and Prof Douglas Neil of the Langoustine Laboratory, University of Glasgow. My recent collaboration with Prof Neil has launched a pilot project utilising the ScotMet Facility at Strathclyde to investigate the ecological implications of the production of secondary metabolites in Crustaceans for an alternative application of utilising the waste products of the by-catch.
International collaboration have been established with the groups of Prof Alan Dobson of the Environmental Research Institute, University College Cork and Prof Ute Hentschel of the Sponge Microbiology Group at the University of Wuerzburg to study the metabolomics of the production of secondary metabolites in marine microbial symbionts both from the cold waters of the Irish Sea and the warm water of the Red Sea.
Houssen WE, Lu Z, Edrada-Ebel RA, Chatzi C, Tucker SJ, Sepčić K, Turk T, Zovko A, Shen S, Mancini I, Scott RH, Jaspars M. DI-SUBSTITUTED PYRIDINIUM POLYMERS AND SYNTHESIS United Kingdom Patent Application No. 0918510.9 CODEN: WO/2010/086652. 2010, International Application No.: PCT/GB2010/050124
Bringmann, G.; Proksch, P.; Edrada, R. A.; Heubes, M.; Gunther, E. „Isolation and synthesis of decalactones from Penicillium species and methods for making pharmaceuticals there from”. U.S. Pat. Appl. Publ., 8 pp. CODEN: USXXCO US 2003216354 A1 20031120. 2003, Application: US 2002-143596 20020509.
MP408 (Formulation, Manufacture & Testing 1) Introduce basic NMR spectroscopy and mass spectrometry used in pharmaceutical analysis to qualitatively and quantitatively identify the drug impurity.
MP916 NMR spectroscopy workshop and Mass Spectrometry in Pharmaceutical Analysis
MP921 (Class Coordinator) Bioanalysis
"Real time matabolic flux modelling in biopharmaceutical bioprocessing"
BBSRC and EPSRC
"Investigating synergies between advanced bioprocess monitoring and production of valuable marine bioproducts."
"Metabolomics of microbial symbionts from Irish Sea Sponges"
Beaufort Marine Biodiversity Program, University College Cork
"Marine symbionts and terrestrial endophytes for Industrial biotechnology of novel antibiotics"
European Research Development Fund and EPSRC
- Chagas-Paula, D.A.; Oliveira, T.B.; Zhang, T.; Edrada-Ebel, R.; Da Costa, F.B (2015) Prediction of anti-inflammatory plants and discovery of their biomarkers by machine learning algorithms and metabolomic studies.. Planta Medica Published (Epub)
- Harvey, A.L.; Edrada-Ebel, R.; Quinn, R.J (2015) The re-emergence of natural products for drug discovery in the genomics era. Nature Reviews Drug Discovery 14, 111-129
- MacIntyre, L.; Zhang, T.; Viegelmann, C.; Martinez, I.J.; Cheng, C.; Dowdells, C.; Abdelmohsen, U.R.; Gernert, C.; Hentschel, U.; Edrada-Ebel, R.* Marine drugs (2014) Metabolomic tools for secondary metabolite discovery from marine microbial symbionts.. 12, 3416-3448
- Viegelmann, C.; Margassery, L.M.; Kennedy, J.; Zhang, T.; O'Brien, C.; O'Gara, F.; Morrissey, J.P.; Dobson, A.D.; Edrada-Ebel, R. Marine Drugs (2014) Metabolomic profiling and genomic study of a marine sponge-associated Streptomyces sp.. 12, 3323-3351
- Zhang, T.; Omar, R.; Siheri, W.; Al Mutairi, S.; Clements, C.; Fearnley, J.; Edrada-Ebel, R.; Watson D.G. (2014) Chromatographic analysis with different detectors in the chemical characterisation and dereplication of african propolis.. Talanta 120, 181-190
Adnan Alkhalil: 'Anti-trypanosomal Active Metabolites from Propolis' (started 2010)
Majed Mansour Madi Al Robaian: 'Preparation and analysis of novel tumour-targeted gene delivery systems for cancer therapy' (started 2011)
Mohammed Mofareh A Albratty: 'Metabonomic analysis of Drosophila mutants' (started 2009)
Sultan Saadi S Almutairi: 'Exploring the glycolytic metabolism of the blood stream forms of trypanosoma brucei using stable isotope labelling and mass spectrometry' (started 2011)
Weqas Alotaibi: 'Metabolomics and how it can be used as a tool in the identification and production of new antibiotics from natural sources' (started 2012)
Enitome Evi Bafor: 'Isolation, identification and pharmacological evaluation of the actives of the leaf extracts of ficus exasperata vahl (moraceae)' (started 2010)
Nurkhalida Binti Kamal: 'Phytochemical study and bioactivities of Vitex Pinnata' (started 2009)
Tantima Kumlung: 'Improved routes to bioprocessing of biopharmaceuticals' (started 2007)
Gareth Lewis: 'Development of a Translational Rabbit QTc Model' (started 2012)
Alison Macfadyen: 'Determination the genetic basis of oxytetracycline productivity for streptomyces rimosus by the correlation of genomic and metabolomic data' (started 2010)
Noor Wini Binti Mazlan: 'Endophytic microbial metabolites from mangrove plants or marine sources' (started 2012)
Ahmed Fares Tawfike: 'Chemical dereplication studies of endophytic and endozoic metabolites of both terrestrial and marine sources by using metabolomics as a tool in the se' (started 2010)
Christina Victoria Viegelmann: 'Metabolomics as a tool in the identification and production of new marine derived antibiotics from the coastlines of the British isles' (started 2010)
Yusnaini Binti Md Yusoff: 'Using metabolomics to study the antiproliferative effect of New Zealand and Malaysian honey fractions on human lung adenocarcinoma epithelial cell lin' (started 2015)
Prof. Ute Hentschel, University Of Wuerzburg
Dr Jonathan Kennedy, University College Cork
Prof. Alan Dobson, University College Cork
Prof. Marcel Jaspars, University Of Aberdeen
Prof. Peter Proksch, University Of Duesseldorf
Prof Douglas Neil, University Of Glasgow
Prof. Dr. Fernando B. Da Costa University Of Sao Paolo