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Professor Roger Wadsworth

Chair in Pharmacology

RW 601P

r.m.wadsworth@strath.ac.uk

Tel : +44(0)141 548 2154 (Ext. 2154)


Profile

Roger Wadsworth is Professor of Cardiovascular Pharmacology and is an Associate Editor for the review journal Pharmacology & Therapeutics. He is the Strathclyde University budget holder for the Centre of Excellence in Integrative Mammalian Biology.

The research focus in Roger Wadsworth's laboratory involves in vivo and in vitro cardiovascular disease models that have features of endothelium dysfunction and vascular pathology. Equally important are the physiological regulatory processes that control vascular function. Artery reconstructive surgery using arterial stents or vein grafts involves abnormal stresses leading to inflammation and neointimal hypertrophy. Usually these resolve but in some cases they can progress so that the artery or graft becomes blocked. Wadsworth’s laboratory found that regrown endothelium has abnormal nitric oxide synthase. Current research aims to understand how to improve vascular healing, whilst also permitting rapid endothelial recovery thus limiting thrombosis and vascular occlusion. Wadsworth’s laboratory found that hypoxia, one of the causes of pulmonary hypertension, causes vasoconstriction by changing the balance of endothelium mediators and reducing NO formation. Pulmonary hypertension in patients is associated with oxidative stress and alterations in nitric oxide synthase. Reactive radicals can stimulate cell growth and current research aims to define the cellular processes affected by reactive oxidative radicals and novel therapeutic approaches to restore activity in dysfunctional NO synthase. The laboratory has developed techniques to measure nitric oxide release simultaneously with relaxation of an artery ring in a myograph.

Roger Wadsworth contributes teaching to MPharm and BSc biomedical science degrees, is the First Year Coordinator for the MPharm degree, and is a member of MPharm Management Committee.

"Capacity Building Award in Integrative Mammalian Biology"
BBSRC

"Importance of mast cells in vein graft survival and failure"
British Heart Foundation

"RAIS Project with Translumina: Succinobucol-releasing stent project"
JOLINE GmbH & Co KG

"Role of fibroblast in pulmonary vascular remodelling: paracrine signalling and molecular mechanics"
Wellcome Trust

"Modelling drug-eluting stents"
EPSRC

"Tetrahydrobiopterin mmimetics as nitric oxide synthase activators"
KIAT

"VAN 10-4 drug-eluting stents"
KIAT

"Vein graft success depends on tissue hypoxia modulating TLR and PLC gamma"
British Heart Foundation

"Toll-like receptor mediated inflammatory mechanisms in vascular proliferative failure of arterio-venous fistulas used for haemodialysis"
BBSRC and SSA

Publications

  • Agbani E.O., Coats P., Mills A. and Wadsworth R.M, (2011) Peroxynitrite stimulates pulmonary artery endothelial and smooth muscle cell proliferation: involvement of ERK and PKC. Pulmonary Pharmacology and Therapeutics 24, 100-109

  • Sean McGinty; Sean McKee; Roger M. Wadsworth; Christopher McCormick (2010) Modelling Drug eluting stents. MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA Published (Epub)

  • Weerackody R P, Welsh DJ, Wadsworth RM, Peacock AJ (2009) Inhibition of p38 MAP Kinase Reverses Hypoxia Induced Pulmonary Artery Endothelial Dysfunction. American Journal of Physiology - Heart and Circulatory Physiology 296, H1312 - H1320 [DOI: 10.1152/ajpheart.00977.2008]

  • Coats, P., Kennedy, S., Pyne, S., Wainwright, C.L. & Wadsworth, R.M. (2008) Inhibition of non-Ras protein farnesylation reduces in-stent restenosis. Atherosclerosis 197, 515-523 [DOI: 10.1016/j.atherosclerosis.2007.06.007]

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Group

Postdoctoral researchers

Dr Christopher Mccormick: 'Modelling drug-eluting stents' (started 2012)

Dr Junxi Wu: 'The role of mast cells in vein graft remodelling and failure' (started 2010)

Postgraduate students

Thomas Carson: 'Vein graft success depends on tissue hypoxia modulating TCR and PLC gamma' (started 2011)

Dr Colin Church: 'The role of p38 MAP kinase in pulmonary hypertension' (started 2009)

Mark Macaskill: 'TLR mediated mechanisms underlying vascular plasticity associated with haemodynamic stress and injury' (started 2010)





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