Roger Wadsworth is Professor of Cardiovascular Pharmacology and is an Associate Editor for the review journal Pharmacology & Therapeutics. He is the Strathclyde University budget holder for the Centre of Excellence in Integrative Mammalian Biology.
The research focus in Roger Wadsworth's laboratory involves in vivo and in vitro cardiovascular disease models that have features of endothelium dysfunction and vascular pathology. Equally important are the physiological regulatory processes that control vascular function. Artery reconstructive surgery using arterial stents or vein grafts involves abnormal stresses leading to inflammation and neointimal hypertrophy. Usually these resolve but in some cases they can progress so that the artery or graft becomes blocked. Wadsworth’s laboratory found that regrown endothelium has abnormal nitric oxide synthase. Current research aims to understand how to improve vascular healing, whilst also permitting rapid endothelial recovery thus limiting thrombosis and vascular occlusion. Wadsworth’s laboratory found that hypoxia, one of the causes of pulmonary hypertension, causes vasoconstriction by changing the balance of endothelium mediators and reducing NO formation. Pulmonary hypertension in patients is associated with oxidative stress and alterations in nitric oxide synthase. Reactive radicals can stimulate cell growth and current research aims to define the cellular processes affected by reactive oxidative radicals and novel therapeutic approaches to restore activity in dysfunctional NO synthase. The laboratory has developed techniques to measure nitric oxide release simultaneously with relaxation of an artery ring in a myograph.
Roger Wadsworth contributes teaching to MPharm and BSc biomedical science degrees, is the First Year Coordinator for the MPharm degree, and is a member of MPharm Management Committee.
"Capacity Building Award in Integrative Mammalian Biology" BBSRC
"Importance of mast cells in vein graft survival and failure" British Heart Foundation
"RAIS Project with Translumina: Succinobucol-releasing stent project" JOLINE GmbH & Co KG
"Role of fibroblast in pulmonary vascular remodelling: paracrine signalling and molecular mechanics" Wellcome Trust
"Modelling drug-eluting stents" EPSRC
"Tetrahydrobiopterin mmimetics as nitric oxide synthase activators" KIAT
"VAN 10-4 drug-eluting stents" KIAT
"Vein graft success depends on tissue hypoxia modulating TLR and PLC gamma" British Heart Foundation
"Toll-like receptor mediated inflammatory mechanisms in vascular proliferative failure of arterio-venous fistulas used for haemodialysis" BBSRC and SSA
Weerackody R P, Welsh DJ, Wadsworth RM, Peacock AJ (2009) Inhibition of p38 MAP Kinase Reverses Hypoxia Induced Pulmonary Artery Endothelial Dysfunction. American Journal of Physiology - Heart and Circulatory Physiology296, H1312 - H1320 [DOI: 10.1152/ajpheart.00977.2008]
Agbani E.O., Coats P., Mills A. and Wadsworth R.M, (2011) Peroxynitrite stimulates pulmonary artery endothelial and smooth muscle cell proliferation: involvement of ERK and PKC. Pulmonary Pharmacology and Therapeutics24, 100-109
Sean McGinty; Sean McKee; Roger M. Wadsworth; Christopher McCormick (2010) Modelling Drug eluting stents. MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA , Published (Epub)
Laurie Shedden, Simon Kennedy, Roger Wadsworth, Patricia Connolly (2010) Towards a self-reporting coronary artery stent – Measuring neointimal growth associated with in-stent restenosis using electrical impedance techniques. Biosensors and Bioelectronics26, 661-666
McDonald, R.M., Pyne, S., Pyne, N.J., Wainwright, C.L. & Wadsworth, R.M. (2010) The sphingosine kinase inhibitor N, N-dimethylsphingosine inhibits neointimal hyperplasia. British Journal of Pharmacology159, 543-553 [DOI: 10.1111/j.1476-5381.2009.00533.x]
Miller MR, Wadsworth RM (2009) Understanding organic nitrates – a vein hope? Commentary on Wenzl et al. “Distinct effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin”.. British Journal of Pharmacology157, 565-567 Published (review)
Thomas Hoehn, Brigitte Stiller, Allan R McPhaden and Roger M Wadsworth (2009) Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. RESPIRATORY RESEARCH10, 110-119
Ross Stevenson, Robert J. Stokes, Donna MacMillan, David Armstrong, Karen Faulds, Roger Wadsworth, Suma Kunuthur, Colin J. Suckling and Duncan Graham (2009) In situ detection of pterins by SERS. Analyst134, 1561-1564 [DOI: 10.1039/b905562b]
Weerackody R P, Welsh DJ, Wadsworth RM, Peacock AJ (2009) Inhibition of p38 MAP Kinase Reverses Hypoxia Induced Pulmonary Artery Endothelial Dysfunction. American Journal of Physiology - Heart and Circulatory Physiology296, H1312 - H1320 [DOI: 10.1152/ajpheart.00977.2008]
Junxi Wu, Roger M. Wadsworth, Simon Kennedy (2011) Inhibition of iNOS promotes vein graft neoadventitial inflammation and remodeling. Journal of Vascular Research48, 141-149
C McCormick, RL Jones, S Kennedy, RM Wadsworth (2010) Activation of prostanoid EP receptors by prostacyclin analogues in the rabbit iliac artery: implications for anti-restenotic potential?. European Journal of Pharmacology641, 160-167
Suma P Kunuthur, Philip H Milliken, Colin L Gibson, Colin J Suckling, Roger M Wadsworth (2010) Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties.. European Journal of Pharmacology650, 371-377
Agbani EO, Coats P, Wadsworth RM (2011) Threshold of peroxynitrite cytotoxicity in bovine pulmonary artery endothelial and smooth muscle cells. Toxicology in Vitro , In Press
Agbani E.O. Coats P. and Wadsworth R.M, (2011) Acute hypoxia stimulates intracellular peroxynitrite formation associated with pulmonary artery smooth muscle cell proliferation.. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY57, 584-588
Agbani E.O., Coats P., Mills A. and Wadsworth R.M, (2011) Peroxynitrite stimulates pulmonary artery endothelial and smooth muscle cell proliferation: involvement of ERK and PKC. Pulmonary Pharmacology and Therapeutics24, 100-109
Sean McGinty; Sean McKee; Roger M. Wadsworth; Christopher McCormick (2010) Modelling Drug eluting stents. MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA , Published (Epub)
Andrew J. Jackson, Paul Coats, Douglas J. Orr, R. Paul Teenan, Roger M. Wadsworth (2010) Pharmacotherapy to Improve Outcomes in Infrainguinal Bypass Graft Surgery: A Review of Current Treatment Strategies. Annals of Vascular Surgery24, 562-572 Published (review)
D. D. Ankola, R. M. Wadsworth and M. N. V. Ravi Kumar (2011) Nanoparticulate delivery can improve peroral bioavailability of cyclosporine and match Neoral Cmax sparing the kidney from damage. Journal of Biomedical Nanotechnology7, 300-307
