I was appointed as Reader in SIPBS at the University of Strathclyde in 2007 and have been Secretary and UK representative to the European Federation of Biotechnology Working Party in Bioreactor Performance for 5 years. I am also coordinator of several significant research programmes funded by GSK/TSB, BBSRC Link, Marlow Foods, Masterfoods, DSM and Roche. My current project partners and sponsors include BBSRC, EPSRC, Ingenza, Aquapharm, FossNIRSystems. I have acted in a consultancy role for many major EU biotechnology and food companies.
My major areas of research interest include understanding the physiology of microbial and animal cell cultures within fermenter and bioreactor systems; bioprocess technology, including reactor and fermenter design; measurement and control in bioprocesses, with particular emphasis on spectroscopic techniques (Near and Mid IR) and data handling. All of these areas have received substantial industrial funding support together with funding from public sources.
My main teaching activities include Fermentation Technology, Intermediate Microbiology, Advanced Microbial Techniques classes, and coordination of the new MSc in Industrial Microbiology. I am also currently Head of Biomedical Sciences Teaching.
"NIR validation of cleaning in a clinical context" Health Facilities Scotland
"Real time matabolic flux modelling in biopharmaceutical bioprocessing" BBSRC and EPSRC
Publications
Zeng-Ping Chen, Li-Jing Zhong, Alison Nordon, David Littlejohn, Megan Holden, Mariana Fazenda, Linda Harvey, Brian McNeil, Jim Faulkner, Julian Morris (2011) Calibration of Multiplexed Fibre Optic Spectroscopy. Analytical Chemistry83, 2655-2659
Q. Li, B.McNeil, LM Harvey (2008) Adaptive response to oxidative stress in the filamentous fungus Aspergillus niger B1-D. Free Radical Biology & Medicine44, 394-402
R.J. Seviour, B. McNeil, M. L. Fazenda, and L. M. Harvey (2011) Operating bioreactors for microbial exopolysaccharide
Production. Critical Reviews in Biotechnology31, 170-185 Published (review)
Q. Li, L.M. Harvey and B McNeil (2009) Oxidative stress in industrial fungi. Critical Reviews in Biotechnology29, 199-213 Published (review)
Ugwuanyi JO, Harvey LM, McNeil B (2008) Protein enrichment of corn cob hetero-xylan waste slurry by thermophilic aerobic digestion using Bacillus stearothermophilus. Bioresource Technology99, 6974-6985
Li Q, Harvey LM, McNeil B (2008) The effects of elevated process temperature on the protein carbonyls in the filamentous fungus, Aspergillus niger B1-D Proc. Biochemical Journal43, 877-881
Zeng-Ping Chen, Li-Jing Zhong, Alison Nordon, David Littlejohn, Megan Holden, Mariana Fazenda, Linda Harvey, Brian McNeil, Jim Faulkner, Julian Morris (2011) Calibration of Multiplexed Fibre Optic Spectroscopy. Analytical Chemistry83, 2655-2659
Q. Li, B.McNeil, LM Harvey (2008) Adaptive response to oxidative stress in the filamentous fungus Aspergillus niger B1-D. Free Radical Biology & Medicine44, 394-402
R.J. Seviour, B. McNeil, M. L. Fazenda, and L. M. Harvey (2011) Operating bioreactors for microbial exopolysaccharide
Production. Critical Reviews in Biotechnology31, 170-185 Published (review)
Q. Li, L.M. Harvey and B McNeil (2009) Oxidative stress in industrial fungi. Critical Reviews in Biotechnology29, 199-213 Published (review)
Ugwuanyi JO, Harvey LM, McNeil B (2008) Protein enrichment of corn cob hetero-xylan waste slurry by thermophilic aerobic digestion using Bacillus stearothermophilus. Bioresource Technology99, 6974-6985
Li Q, Harvey LM, McNeil B (2008) The effects of elevated process temperature on the protein carbonyls in the filamentous fungus, Aspergillus niger B1-D Proc. Biochemical Journal43, 877-881
Q. Li, LM Harvey and B McNeil (2008) The effects of bioprocess parameters on extracellular proteases in a recombinant Aspergillus niger B1-D. Applied Microbiology and Biotechnology78, 333-341 [DOI: 10.1007/s00253-007-1298-9]
Ioannis Voulgarisa, S. Alison Arnoldb, Robert Speightb, Linda M. Harvey, Brian McNeil
(2011) Effects of dissolved oxygen availability and culture biomass at induction upon the intracellular expression of monoamine oxidase by recombinant E. coli in fed batch bioprocesses. Process Biochemistry46, 721-729 [DOI: 10.1016/j.procbio.2010.11.019 ]
Li Q, Harvey LA, McNeil B (2008) Oxygen enrichment effects on protein oxidation, proteolytic activity and the energy status of submerged batch cultures of Aspergillus niger B1-D. Process Biochemistry43, 238-243 [DOI: 10.1016/j.procbio.2007.11.016]
El-Sabbagh N, Harvey LM, McNeil B (2008) Effects of dissolved carbon dioxide on growth, nutrient consumption, cephalosporin C synthesis and morphology of Acremonium chrysogenum in batch cultures. Enzyme and Microbial Technology42, 315-324
Li Q, Abrashev R, Harvey LM, McNeil B.
(2008) Oxidative stress-associated impairment of glucose and ammonia metabolism in the filamentous fungus, aspergillus niger b1-D. Mycological Research112, 1049-1055 [DOI: 10.1016/j.mycres.2008.03.004]
J.O.Ugwuanyi, LM Harvey and B. McNeil (2008) Diversity of thermophilic populations during thermophilic aerobic digestion of agricultural wastes for animal nutrition. Journal of Applied Microbiology104, 79-90
Fazenda ML, Seviour R, McNeil B, Harvey LM.
(2008) Submerged culture fermentation of "higher fungi": the macrofungi. Advances in Applied Microbiology63, 33-103
Li,Q., Bai, Z., O'Donnell, A., Hoskisson P.A., Harvey, L.M. and McNeil, B. (2011) Oxidative stress in fungal fermentation processes: the roles of alternative respiration. BIOTECHNOLOGY LETTERS33, 457-467 Published (review)
Finn, B., Harvey, L.M., and McNeil, B (2010) The effect of dilution rate on protein content and amino acid profiles in chemostat cultures of Saccharomyces cerevisiae CABI 039916. International Journal of Food Engineering6, 1-21 [DOI: 10.2202/1536-3758.1753]
A O’Donnell, LM Harvey and B McNeil (2011) The roles of the alternative NADH dehydrogenases during oxidative stress in cultures of the filamentous fungus Aspergillus niger.. Fungal Biology115, 359-369 [DOI: 10.1016/j.funbio.2011.01.007]
Fazenda, M, Harvey, L.M., and McNeil, B. (2010) Effects of dissolved oxygen on fungal morphology and process rheoleogy during fed-batch processing of Ganoderma lucidum. Journal of Microbiology and Biotechnology , 844-851 [DOI: 10.4014/jmb.0911.11020]
Dr Mariana Fazenda: 'Real time metabolic flux modelling in biopharmaceutical bioprocessing' (started 2010)
Postgraduate students
Wimonmat Boonmee: 'Design and Evaluation of bacteriophage production and purification' (started 2005)
Peter Gardner: 'Real time monitoring of commercial biocatalysis processes using near and mid infrared spectroscopes' (started 2008)
Ebtihaj Jambi: 'The oscillatory baffled bioreactor in bioprocessing' (started 2006)
Ivo Maria Joseph Kretzers: 'Oxidative stress in submerged culture of cells' (started 2009)
Tantima Kumlung: 'Improved routes to bioprocessing of biopharmaceuticals' (started 2007)
Alex Mcdowall (started 2003)
Shivani Tyagi: 'Near infrared spectroscopy and scale up' (started 2007)
Ioannis Voulgaris: 'The production of industrially relevant enzymes using novel organisms and expression systems with new scalable fermentation technologies' (started 2007)
