I am a John Anderson Research Lecturer in in vivo Biology with particular interests in brain damage and repair. Previously I registered as a Pharmacist in 1992 and obtained my PhD in 1996 at University of Glasgow during which I developed a deep interest in brain damage. I pursued my academic career in stroke research as a postdoctoral researcher and latterly a research fellow at the Wellcome Surgical Institute, University of Glasgow before joining SIPBS in 2007.
My research focuses on making a contribution to understanding mechanisms of brain damage and repair using two strategies namely inflammation and stem cells. I have particular interest in in vivo models of brain damage and in in vivo brain imaging to allow quantitative live cell tracking by multiphoton microscopy at Centre for Biophotonics. Current research programmes include understanding how to promote success of stem cells after stroke (with Robin Plevin) and the roles of endocannabinoids, mast cells and T cells in stroke (with Susan Coker and Catherine Lawrence). Externally, we maintain strong collaborative links with stroke clinicians and with Dr Mike Modo (Kings College London), Professors Mhairi Macrae, Paul Garside, Drs Jim Brewer and Pasquale Maffia (University of Glasgow) and Dr Maria Grazia De Simoni (Milan).
I aim to generate student engagement and research aspirations in Pharmacy and Biomedical Science students and to promote opportunities of science in interdisciplinary areas using techniques ranging from one-to-one supervision, didactic sessions, interactive MCQ and web tutorials.
Publications
Fumagalli, S, Coles, JAC, Ejlerskov, P., Ortolano, F., Bushell, T. J., Brewer, J.M., De Simoni, M.G., Dever, G., Garside, P., Maffia, P., Carswell, H.V.
(2011) In vivo Real Time Imaging of T Lymphocyte Dynamics in Mouse Brain by Multiphoton Microscopy After Stroke.. Stroke42, 1429-1436
Mittal, G., Carswell H., Currie S., Brett R. and Ravi Kumar M.N.V
(2011) Development and evaluation of polymer nanoparticles for oral delivery of estradiol to rat brain in a model of Alzheimer's pathology. Journal of Controlled Release150, 220-228 [DOI: 10.1016/j.jconrel.2010.11.013 ]
Ortolano, F., Maffia, P., Dever, G., Rodolico, G., Millington, O.R., De Simoni, M.G., Brewer, J.M., Bushell, T.J., Garside, P. and Carswell H.V. (2010) Advances in imaging of new targets for pharmacological intervention in stroke: real time tracking of T cells in the ischaemic brain. British Journal of Pharmacology159, 808-811
Carswell, H.V.O, Macrae I.M., Farr T.D, (2009) Complexities of Oestrogen in Stroke. Clinical Science118, 375-389 Published (review)
Patkar S., Tate R., Modo M., Plevin R., Carswell H.V.O. (2011) Conditionally immortalised neural stem cells improves promote functional recovery and brain plasticity after transient focal ischaemia in mice.. Stem Cell Research , [DOI: 10.1016/j.scr.2011.07.001] In Press
Fumagalli, S, Coles, JAC, Ejlerskov, P., Ortolano, F., Bushell, T. J., Brewer, J.M., De Simoni, M.G., Dever, G., Garside, P., Maffia, P., Carswell, H.V.
(2011) In vivo Real Time Imaging of T Lymphocyte Dynamics in Mouse Brain by Multiphoton Microscopy After Stroke.. Stroke42, 1429-1436
Mittal, G., Carswell H., Currie S., Brett R. and Ravi Kumar M.N.V
(2011) Development and evaluation of polymer nanoparticles for oral delivery of estradiol to rat brain in a model of Alzheimer's pathology. Journal of Controlled Release150, 220-228 [DOI: 10.1016/j.jconrel.2010.11.013 ]
Ortolano, F., Maffia, P., Dever, G., Rodolico, G., Millington, O.R., De Simoni, M.G., Brewer, J.M., Bushell, T.J., Garside, P. and Carswell H.V. (2010) Advances in imaging of new targets for pharmacological intervention in stroke: real time tracking of T cells in the ischaemic brain. British Journal of Pharmacology159, 808-811
Carswell, H.V.O, Macrae I.M., Farr T.D, (2009) Complexities of Oestrogen in Stroke. Clinical Science118, 375-389 Published (review)
Patkar S., Tate R., Modo M., Plevin R., Carswell H.V.O. (2011) Conditionally immortalised neural stem cells improves promote functional recovery and brain plasticity after transient focal ischaemia in mice.. Stem Cell Research , [DOI: 10.1016/j.scr.2011.07.001] In Press
Farr, T.D., Carswell, H.V.O., McCann, D.J., Sato, M., Bryant, H.U., Dodge, J.A. and Macrae, I.M (2008) The selective oestrogen receptor modulator, LY362321 is not neuroprotective in a rat model of transient focal ischaemia. Journal of Neuroendocrinology20, 366-374 [DOI: 10.1111/j.1365-2826.2008.01648.x]
Ortolano, F., Maffia, P., Dever, G., Hutchison, S., Benson, R., Millington, O.R., De Simoni, M.G., Bushell, T.J., Garside, P., Carswell, H.V. and Brewer, J.M. (2008) Imaging T-cell movement in the brain during Experimental Cerebral Malaria. Parasite Immunology31, 147-150 [DOI: 10.1111/j.1365-3024.2008.01090.x]
Patkar, S., Farr, T.D., Cooper, E., Dowell, F.J., Carswell, H.V. O. (2011) Differential vasoactive effects of oestrogen, oestrogen receptor agonists and selective oestrogen receptor modulators in rat middle cerebral artery. Neuroscience Research71, 78-84 [DOI: 10.1016/j.neures.2011.05.006 ]
