"Optimizing Inhibitors of T. gondii ENR" National Institute for Health (NIH)
"Towards a vaccine for Toxoplasmosis" National Institute for Health (NIH)
Publications
Bobat S, Flores-Langarica A, Hitchcock J, Marshall JL, Kingsley RA, Goodall M, Gil-Cruz K, Serre K, Leyton D, Letran SL, Gaspal F, Chester R, Dougan G, López-Macías C, Henderson IR, Alexander J, MacLennan ICM, Cunningham AF (2011) Soluble flagellin, FliC, induces an antigen-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella Typhimurium infection.. Journal of Immunology41, 1606-1618
Menzies FM, Henriquez FL, Alexander J, Roberts CW (2011) Selective inhibition and augmentation of alternative macrophage activation by progesterone.. Immunology134, 281-291 [DOI: 10.1111/j.1365-2567.2011.03488.x.]
Al-Mutairi MS, Cadalbert LC, McGachy HA, Shweash MS, Schroeder J, Kurnik M, Sloss CM, Bryant CE, Alexander J and Plevin R (2010) MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLoS Pathogens6, e1001192
Henriquez, F.L., Campbell, S.A., ROBERTS, C.W., Mullen, A.B., Burchmore R. and Carter, K.C. (2010) Vaccination with recombinant L. donovani gamma-glutamylcysteine synthetase fusion protein protects against Leishmania donovani infection. Journal of Parasitology96, 929-936
Henriquez, F.L., Woods, S., Cong, H., McLeod, R. and Roberts, C.W.
(2010) Immunogenetics of Toxoplasma gondii informs vaccine design. Trends in Parasitology26, 550-555 [DOI: 10.1016/j.pt.2010.06.004 ] Published (review)
Jones LA, Kreem S, Shweash M, Paul A, Alexander J, Roberts CW. (2010) Differential modulation of TLR3- and TLR4-mediated dendritic cell maturation and function by progesterone. Journal of Immunology185, 4525-4534
Bobat S, Flores-Langarica A, Hitchcock J, Marshall JL, Kingsley RA, Goodall M, Gil-Cruz K, Serre K, Leyton D, Letran SL, Gaspal F, Chester R, Dougan G, López-Macías C, Henderson IR, Alexander J, MacLennan ICM, Cunningham AF (2011) Soluble flagellin, FliC, induces an antigen-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella Typhimurium infection.. Journal of Immunology41, 1606-1618
Menzies FM, Henriquez FL, Alexander J, Roberts CW (2011) Selective inhibition and augmentation of alternative macrophage activation by progesterone.. Immunology134, 281-291 [DOI: 10.1111/j.1365-2567.2011.03488.x.]
Al-Mutairi MS, Cadalbert LC, McGachy HA, Shweash MS, Schroeder J, Kurnik M, Sloss CM, Bryant CE, Alexander J and Plevin R (2010) MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLoS Pathogens6, e1001192
Henriquez, F.L., Campbell, S.A., ROBERTS, C.W., Mullen, A.B., Burchmore R. and Carter, K.C. (2010) Vaccination with recombinant L. donovani gamma-glutamylcysteine synthetase fusion protein protects against Leishmania donovani infection. Journal of Parasitology96, 929-936
Henriquez, F.L., Woods, S., Cong, H., McLeod, R. and Roberts, C.W.
(2010) Immunogenetics of Toxoplasma gondii informs vaccine design. Trends in Parasitology26, 550-555 [DOI: 10.1016/j.pt.2010.06.004 ] Published (review)
Jones LA, Kreem S, Shweash M, Paul A, Alexander J, Roberts CW. (2010) Differential modulation of TLR3- and TLR4-mediated dendritic cell maturation and function by progesterone. Journal of Immunology185, 4525-4534
Jones LA, Roberts F, McKenzie ANJ, Henriquez FL, Alexander J and Roberts C.W. (2010) IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii. European Journal of Immunology40, 426-436
Karen J. Bryson, Owain R. Millington, Thabang Mokgethi H. Adrienne McGachy, Frank Brombacher and James Alexander (2010) BALB/c mice deficient in CD4 T cell IL-4Rα expression control leishmania mexicana Load although female but not male mice develop a healer phenotype. PLOS Neglected Tropical Diseases5, e930
Millington OR, Myburgh E, Mottram JC, Alexander J. (2010) Imaging of the host/parasite interplay in cutaneous leishmaniasis.. Experimental Parasitology126, 310-317
ROBERTS, C.W. and Henriquez, F.L. (2010) Drug target identification, validation, characterisation and exploitation in Acanthamoeba. Experimental Parasitology126, 91-96 Published (review)
Tipparaju, S., Muench, S., Mui,E., Ruzheinikov, S., Lu, J., Hutson, S., Kirisits, M., Prigge, S., Roberts, C.W., Henriquez, F., Kozikowski, l., Rice, D. and McLeod, R. (2010) Identification and development of novel inhibitors of Toxoplasma gondii Enoyl Reductase.. Journal of Medicinal Chemistry53, 6287-6300 [DOI: 10.1021/jm9017724]
Henriquez S.A., Brett R., Alexander J., Pratt J., Roberts C.W. (2009) Neuropsychiatric disease and Toxoplasma gondii infection. Neuroimmunomodulation16, 122-133 [DOI: 10.1159/000180267 ] Published (review)
Henriquez, F.L. and ROBERTS, C.W. (2009) A century of Toxoplasma gondii research. Microbiology Today36, 192-195 Published (review)
Henriquez, F.L., McBride, J., Campbell, S.J., Ramos, T., Ingram, P.R., Roberts, F., Tinney, S. & ROBERTS, C.W. (2009) Acanthamoeba alternative oxidase genes: Identification, characterisation and potential as antimicrobial target.. International Journal for Parasitology39, 1417-1424 [DOI: 10.1016/j.ijpara.2009.04.011]
Henriquez, F.L., Menzies, F.M. & ROBERTS, C.W (2009) Sex Hormones and Immunity to Infection (ROBERTS & Klein Eds) Springer, Ch.9. Pregnancy and susceptibility to parasites. Book Chapter ,
Jongert, E., Gargano, N., Foerster-waldl, E. ROBERTS, C.W. & Petersen, E.K. (2009) Vaccines against Toxoplasma gondii: challenges and opportunities.. Memorias do Instituto Oswald Cruz104, 252-266 Published (review)
Klein, S., & ROBERTS, C.W. (2009) Sex Hormones and Immunity to Infection, Springer. (ISBN 978-3-642-02154-1). Book Edited ,
Menzies, F., Henriquez,, F.L., Alexander, J. and ROBERTS, C.W. (2009) Sequential expression of macrophage antimicrobial/inflammatory and wound healing markers following innate, alternative and classical activation. Clinical and Experimental Immunology 160, 369-379
Mukhopadhyay A, Chen, C.Y., Loeb, L.A., Doerig, C., Henriquez, F.L., ROBERTS, C.W., Barrett, M.P. (2009) The Toxoplasma gondii plastid replication and repair enzyme complex, PREX.. Parasitology136, 747-755 [DOI: 10.1017/S0031182009006027]
ROBERTS, C.W. & Klein, SA. (2009) Sex Hormones and Immunity to Infection (ROBERTS & Klein Eds) Springer, Ch.12 Challenges for the future.. Book Chapter ,
Hermes, G., Ajioka, J.W., Kelly, K.A. Mui, E.J. Roberts, F., Kasza, K., Mayr, T., Kirisits, M.J., Wollman, R., Ferguson, D.J.P., ROBERTS, C.W., Hwang, J-H., Kennan, R.P., Suzuki, Y., Reardon, C., Hickey, A.W., Trendler, T., Chen, L. & McLeod, R. (2008) Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection.. Journal of Neuroinflammation5, [DOI: 10.1186/1742-2094-5-48 ]
Campbell, S.J. Ingram, P.R., ROBERTS, C.W. & Henriquez, F.L. (2008) Induced encystment improves resistance to preservation and storage of Acanthamoeba castellanii.. Parasitology135, 1401-1405 [DOI: 10.1017/S0031182008005003]
Henriquez, F.L., Ingram, P.R., Muench, S.P. Rice, D. & ROBERTS, C.W. (2008) A molecular basis for the resistance of Acanthamoeba tubulins to all major classes of anti-tubulin. Antimicrobial Agents and Chemotherapy52, 1133-1135 [DOI: 10.1128/AAC.00355-07]
Jones L.A., Anthony J.P., Henriquez F.L., Lyons R.E., Nickdel M.B., Carter K.C., Alexander J., Roberts C.W. (2008) Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors Immunology. Immunology125, 59-69
Menzies, F.M., Henriquez, F.L. & ROBERTS, C.W. (2008) Immunological control of congenital toxoplasmosis in the murine model.. Immunology Letters115, 83-89
Mui, E.J., Schiehser, G.A., Milhous, W.K., Hsu, H., ROBERTS, C.W., Kirisits, M., Muench, S., Rice, D., Dubey, J.P., Fowble, J.W., Rathod, P.K., Queener, S.F., Liu, S.R., Jacobus, D.P., and McLeod, R. (2008) Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. PLOS Neglected Tropical Diseases2, e190 [DOI: 10.1371/journal.pntd.0000190]
