Clive Wilson is the J. P. Todd Professor of Pharmaceutics at Strathclyde University and the current president of the European Union Federation of Pharmaceutical Sciences. He completed his Ph.D. with Professor Dennis Parke in drug metabolism at the University of Surrey. His first position was an Asthma Research Council Fellow at the Cardiothoracic Institute, London becoming a Lecturer in Biochemical Pharmacology and moving to Nottingham Medical School to become Reader in Applied Pharmacology.
Major areas of research have been the study of the behaviour of drug formulations in man. With colleagues at Nottingham, he pioneered applications of scintigraphy in the study of physiological and patho-physiological effects on drug absorption following oral, nasal, pulmonary and ophthalmic delivery. These activities have continued at Glasgow Royal infirmary through (BioImages Research Ltd). In the university, his group are working on ophthalmic drug delivery projects especially the behaviour of ocular implants. The group are also developing novel optical technology to look at ocular and dental drug delivery systems in association with Durham University. Recent new areas of interest include hyperspectral imaging for the investigation of surface changes on dosage forms which control drug exposure. His group are also exploring finite element modelling of drug distribution in the eye
Primary Teaching activities are in the field of Biopharmaceutics and formulation research.
"Retinal Drug Delivery" Allergan
"Tissue permeability for enhanced drug delivery." GlaxoSmithKline Research & Development Ltd
"The development of a Raman based detection for the identification and quantification of residual Carbopol ETD 2020 delivered from a toothpaste formulation onto teeth for in vitro and in vivo detection" GlaxoSmithKline
"Ultreasound for opthalmic implants" Allergan
Publications
Laude A, Tan L. E., Wilson C. G., Lascaratos G., Elashry M., Aslam T., Patton N., Dhillon B. (2010) Intravitreal therapy for neovascular age-related macular degeneration and inter-individual variations in vitreous pharmacokinetics. Progress in Retinal and Eye Research29, 466-475 Published (review)
Kek W K., Foulds W S., McConnell G, Wright A J, Girkin J M & Wilson C G. (2010) Two-photon fluorescence excitation microscopy to assess trans-scleral diffusional pathways in an isolated perfused bovine eye model. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE51, 5182-5189 [DOI: doi:10.1167/iovs.09-3854 ]
Tan L.E. Wilson C G, Burke J, Orilla W, Hughes P J. (2010) Effects of vitreous liquefaction on the intravitreal distribution of sodium fluorescein, fluorescein dextran and fluorescent microparticles. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE , In Press
Goodman K., Hodges L.A., Band J., Stevens H.N.E., Weitschies W., Wilson C.G. (2010) Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy. European Journal of Pharmaceutics and Biopharmaceutics74, 84-92
Kek W K K, Miller J., Rawson-Lax E., Wilson C.G., Uttamchandani D. (2010) An in situ measurement of spectral changes in the anterior eye following application of ultraviolet absorbing compounds. European Journal of Pharmaceutics and Biopharmaceutics75, 200-205
Shah H.K., Conkie J.A., Tait R.C., Johnson J. R. and Wilson C. G
(2011) A novel, biodegradable and reversible polyelectrolyte platform for topical-colonic delivery of pentosan polysulphate. International Journal of Pharmaceutics404, 124-132
Laude A, Tan L. E., Wilson C. G., Lascaratos G., Elashry M., Aslam T., Patton N., Dhillon B. (2010) Intravitreal therapy for neovascular age-related macular degeneration and inter-individual variations in vitreous pharmacokinetics. Progress in Retinal and Eye Research29, 466-475 Published (review)
Kek W K., Foulds W S., McConnell G, Wright A J, Girkin J M & Wilson C G. (2010) Two-photon fluorescence excitation microscopy to assess trans-scleral diffusional pathways in an isolated perfused bovine eye model. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE51, 5182-5189 [DOI: doi:10.1167/iovs.09-3854 ]
Tan L.E. Wilson C G, Burke J, Orilla W, Hughes P J. (2010) Effects of vitreous liquefaction on the intravitreal distribution of sodium fluorescein, fluorescein dextran and fluorescent microparticles. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE , In Press
Goodman K., Hodges L.A., Band J., Stevens H.N.E., Weitschies W., Wilson C.G. (2010) Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy. European Journal of Pharmaceutics and Biopharmaceutics74, 84-92
Kek W K K, Miller J., Rawson-Lax E., Wilson C.G., Uttamchandani D. (2010) An in situ measurement of spectral changes in the anterior eye following application of ultraviolet absorbing compounds. European Journal of Pharmaceutics and Biopharmaceutics75, 200-205
Shah H.K., Conkie J.A., Tait R.C., Johnson J. R. and Wilson C. G
(2011) A novel, biodegradable and reversible polyelectrolyte platform for topical-colonic delivery of pentosan polysulphate. International Journal of Pharmaceutics404, 124-132
Wilson C G (2010) The transit of dosage forms through the colon. International Journal of Pharmaceutics395, 17-25 Published (review)
Hodges L.M., Connolly S.M., Band J., O’Mahony B., Ugurlu M. Turkoglu M. Wilson C.G. ,Stevens H.N.E. (2009) Scintigraphic evaluation of colon targeting pectin-HPMC tablets in healthy volunteers. International Journal of Pharmaceutics370, 144-150
Wilson C.G., O’Mahony B., Connolly S.M., Cantarini M.V., Farmer M.R., Dickinson P.A., Smith R.P., Swaisland H.C (2009) Do gastrointestinal transit parameters influence the pharmacokinetics of gefitinib?. International Journal of Pharmaceutics376, 7-12
McConville JT, O’Mahony, B., Lindsay B., Ross AC., Florence AJ, Stanley AJ, Humphrey MJ, Wilson CG & Stevens HNE (2009) A Pharmacoscintigraphic Study of Three Time-Delayed Capsule Formulations in Healthy Male Volunteers. Journal of Pharmaceutical Sciences98, 4251-4263
Wilson C.G., Clarke C P., Starkey Y Y., Clarke G D (2010) Comparison of a novel fast dissolving acetaminophen tablet formulation (FD-APAP) and standard acetaminophen tablets using gamma scintigraphy and pharmacokinetic studies. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY , In Press
C G Wilson, W Weischies & J.M Butler (2009) ‘Gastrointestinal transit and drug absorption.’ in Oral drug Absorption 2nd edition ed. Dressman JD & Lennernas H , Marcel Dekker, New York.. Book Chapter ,
C.G.Wilson & W. Weitschies (2009) 'Modern Drug Delivery: Physiological considerations for orally administered medications' in ‘Drug Bioavailability, Estimation of solubility, permeability, absorption and bioavailability. Ed van de Waterbeemd, Wiley-VCH Verlag, Weinheim. Book Chapter , 571-595
Daniel Bar-Shalom, Clive G. Wilson & Neena Washington (2009) ‘Chronotherapy using Egalet® technology’ in Chronopharmaceutics: Science and Technology for Biological Rhythm-Guided Therapy and Prevention of Diseases, edited by Bi-Botti C. Youan. Publishers: Wiley & Sons, Inc Hoboken N.J.. Book Chapter , 165-173
