Expertise in crystallisation screening and crystallisation of pharmaceuticals including polymorphism, solvate formation, salt selection and co-crystal formation. Physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and pharmaceutical properties. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys using variable-temperature X-ray powder diffraction.
EPSRC Funded PhD Position available (Autumn 2011)
This 3.5 year project will study the Formation of Optimised Particles for Formulation and Processing and is funded by the recently established EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (www.cmac.ac.uk) and will be based in the new multidisciplinary laboratory for crystallisation and solid-state research within SIPBS. For more information please contact: alastair.florence@strath.ac.uk.
"EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation" EPSRC
"Control and Prediction of the Organic Solid-State (CPOSS): Translating the Technology " EPSRC
"Crystal engineering approaches to obtaining diffraction quality samples of new chemical entities " Industry-funded
"Physical Organic Chemistry: Opportunities in Synthesis, Materials and Pharmaceuticals" EPSRC
"Basic Technology: Control and Prediction of the Organic Solid State" EPSRC
Publications
Mínguez Espallargas G, van de Streek J, Fernandes P, Florence AJ, Brunelli M, Shankland K, Brammer L. (2010) Mechanistic insights into a gas-solid reaction in molecular crystals: the role of hydrogen bonding. Angewandte Chemie49, 8892-8896
Erin V. Iski, Blair F. Johnston, Alastair J. Florence, Andrew J. Urquhart, and E. Charles H. Sykes (2010) Surface-Mediated Two-Dimensional Growth of the Pharmaceutical Carbamazepine. ACS Nano4, 5061-5068
Andrea Johnston, Julie Bardin, Blair F. Johnston, Philippe Fernandes, Alan R. Kennedy, Sarah L. Price, and Alastair J. Florence
(2011) Experimental and Predicted Crystal Energy Landscapes of Chlorothiazide. CRYSTAL GROWTH & DESIGN11, 405-413 [DOI: 10.1021/cg1010049]
Dykhne, T., Taylor, R., Florence, A. & Billinge, S. J. L. (2011) Data requirements for the reliable use of atomic pair distribution functions in amorphous pharmaceutical fingerprinting. Pharmaceutical Research28, 1041-1048 [DOI: 10.1007/s11095-010-0350-0]
Jean-Baptiste Arlin, Andrea Johnston, Gary J. Miller, Alan R. Kennedy, Sarah L. Price and Alastair J. Florence
(2010) A predicted dimer-based polymorph of 10,11-dihydrocarbamazepine (Form IV). CrystEngComm12, 64-66
Mínguez Espallargas G, van de Streek J, Fernandes P, Florence AJ, Brunelli M, Shankland K, Brammer L. (2010) Mechanistic insights into a gas-solid reaction in molecular crystals: the role of hydrogen bonding. Angewandte Chemie49, 8892-8896
Erin V. Iski, Blair F. Johnston, Alastair J. Florence, Andrew J. Urquhart, and E. Charles H. Sykes (2010) Surface-Mediated Two-Dimensional Growth of the Pharmaceutical Carbamazepine. ACS Nano4, 5061-5068
Arlin, J., Price, L. S., Price, S. L. & Florence, A. J. (2011) A strategy for producing predicted polymorphs: catemeric carbamazepine form V. Chemical Communications47, 7074-7076 [DOI: 10.1039/c1cc11634g]
Iski, E. V., Johnston, B. F., Florence, A. J., Sykes, E. C. H. & Urquhart, A. J. (2011) Carbamazepine on a carbamazepine monolayer forms unique 1D supramolecular assemblies. Chemical Communications47, 9627-9629 [DOI: 10.1039/c1cc13590b]
Andrea Johnston, Julie Bardin, Blair F. Johnston, Philippe Fernandes, Alan R. Kennedy, Sarah L. Price, and Alastair J. Florence
(2011) Experimental and Predicted Crystal Energy Landscapes of Chlorothiazide. CRYSTAL GROWTH & DESIGN11, 405-413 [DOI: 10.1021/cg1010049]
Braun, D. E., Karamertzanis, P. G., Arlin, J., Florence, A. J., Kahlenberg, V., Tocher, D. A., Griesser, U. J. & Price, S. L. (2011) Solid-state forms of β-resorcylic acid how exhaustive should a polymorph screen be?. CRYSTAL GROWTH & DESIGN11, 210-220 [DOI: 10.1021/cg101162a]
Dykhne, T., Taylor, R., Florence, A. & Billinge, S. J. L. (2011) Data requirements for the reliable use of atomic pair distribution functions in amorphous pharmaceutical fingerprinting. Pharmaceutical Research28, 1041-1048 [DOI: 10.1007/s11095-010-0350-0]
Alan R. Kennedy, Alastair J. Florence, Fiona J. McInnes and Nial J. Wheate (2009) A chemical preformulation study of a host-guest complex of cucurbit[7]uril and a multinuclear platinum agent for enhanced anticancer drug delivery. Dalton Transactions2009, 7695-7000 [DOI: 10.1039/b907917c]
Jean-Baptiste Arlin, Andrea Johnston, Gary J. Miller, Alan R. Kennedy, Sarah L. Price and Alastair J. Florence
(2010) A predicted dimer-based polymorph of 10,11-dihydrocarbamazepine (Form IV). CrystEngComm12, 64-66
Simon J. L. Billinge, Timur Dykhne, Pavol Juhás, Emil Božin, Ryan Taylor, Alastair J. Florence and Kenneth Shankland
(2010) Characterisation of amorphous and nanocrystalline molecular materials by total scattering. CrystEngComm12, 1366-1368 [DOI: DOI: 10.1039/B915453A]
Lynne H. Thomas, Alastair J. Florence and Chick C. Wilson
(2009) Hydrogen atom behaviour imaged in a short intramolecular hydrogen bond using the combined approach of X-ray and neutron diffraction. New Journal of Chemistry33, 2486-2490 [DOI: 10.1039/B908915B]
McConville JT, O’Mahony, B., Lindsay B., Ross AC., Florence AJ, Stanley AJ, Humphrey MJ, Wilson CG & Stevens HNE (2009) A Pharmacoscintigraphic Study of Three Time-Delayed Capsule Formulations in Healthy Male Volunteers. Journal of Pharmaceutical Sciences98, 4251-4263
Antoniadis CD, D'Oria E, Karamertzanis PG, Tocher DA, Florence AJ, Price SL, Jones AG.
(2010) A Computationally Inspired Investigation of the Solid Forms of (R)-1-Phenylethylammonium-(S)-2-phenylbutyrate. Chirality22, 447-455
Fielding, L., McKellar, S. C. & Florence, A. J. (2011) Precision studies in supramolecular chemistry: a 1H NMR study of hydroxymethoxyacetophenone/β-cyclodextrin complexes. Magnetic Resonance in Chemistry49, 405-412 [DOI: 10.1002/mrc.2762]
Fabbiani, F. P. A., Arlin, J. B., Buth, G., Dittrich, B., Florence, A. J., Herbst-Irmer, R. & Sowa, H. (2011) Intermolecular interactions, disorder and twinning in ciprofloxacin-2,2-difluoroethanol (2/3) and ciprofloxacin-water (3/14.5). Acta Crystallographica Section C: Crystal Structure Communications67, 120-124 [DOI: 10.1107/S0108270111005488]
A.J. Florence, J. Bardin, B. Johnston, N. Shankland and K. Shankland (2009) Structure determination from powder data: Mogul and CASTEP. Zeitschrift fur Kristallografie30, 215-220
K. Shankland, T. A. N. Griffin, J. van de Streek, J. C. Cole, N. Shankland, A. J. Florence and W. I. F. David (2009) Large-scale distributed computing for accelerated structure solution. Zeitschrift fur Kristallografie30, 227-232
J. Bardin, A. R. Kennedy, L. V. Wong, B. F. Johnston and A. J. Florence (2009) Nicotinamide-2,2,2-trifluoroethanol (2/1). Acta Crystallographica Section E-Structure Reports Online65, O727-U1769 [DOI: 10.1107/S1600536809007594]
A.J. Florence (2009) “The Solid State” in Modern Pharmaceutics, Volume 1, Basic Principles and systems, 5th Edn. Eds. A. T. Florence, and J. Siepmann, Informa Healthcare, New York. Book Chapter ,
Florence AJ (2009) “Approaches to High-Throughput Physical Form Screening and Discovery", in Polymorphism in Pharmaceutical Solids, Eds Brittain, H., 2nd Edition, Informa Healthcare. Book Chapter5,
Naomi Briggs: 'Control of nucleation and growth in continuous crystallisation processes ' (started 2010)
Cheska Marie Gillespie: 'Precipitation of candidate drugs on mixing DMSO solutions with water.' (started 2009)
Gracie Love Kerr: 'Probing the potential of branched polymers as biomaterials' (started 2009)
Scott Campbell Mckellar: 'Crystal engineering to obtain diffraction quality samples of pharmaceuticals' (started 2008)
Rajni Miglani: 'Development of computational model for prediction of solid state forms of pharmaceuticals' (started 2009)
Gary James Miller: 'A Structural Database for Pharmaceutical Salt Selection' (started 2006)
Laura Kathleen Palmer: 'Development of in situ and non-invasive measurement technques for monitoring and control of crystallisation reactions' (started 2010)
Ryan Taylor: 'Structural insights into pharmaceutical polymorphs, solvates and salts from synchrotron and laboratory powder diffraction data' (started 2008)
Robert Donald Young: 'Optimisation of diffraction quality samples through controlled crystallisation' (started 2010)
