Updates:

Record To Disk: Continuous recording option added.

Ampmodule.pas: Copied from WinWCP.Axoclamp 900A updated, not tested yet with hardware. SealTest.pas: Pulse rate now faster. Holding potential now updated for Ao channels selected by tick box.

Bug Fixes

Digidata 1440-1550B: Now searches correct Axoscope program folder for device driver DLLs on Windows 64 bit systems.

Detect Events: Vertical display area of detection criterion display no longer drifts off scale when user shifts zero level.

Bug Fix

Import: Now  imports samlpling interval and A/D voltage range from WCP files contiaining no more than one record.

Noise Analysis: Varianxe plot and power spectrum plots now much faster after progress reporting text made more efficent.

Event Detection: Baseline tracking in threhold detection mode can now be disabled.

Bug Fix 

Amplifiers: Heka EPC-800 current command output now allocated to a different analog out channel since this amplifier has separate voltage- and current-clamp command inputs.

Bug Fixes

Tecella Pico: Junction potential offset determined in voltage-clamp mode now subtracted from membrane potential in current-clamp mode. Current stimulus bias current offset can now be added to set stimulus current to zero current-clamp mode. Input selection now adjusted to maintain connection to headstage or model when switching between current- and voltage-clamp modes.

Update:

Record to Disk: Start on Record option added, allowing stimulus protocols to be automatically started when the Record button is pressed.

Bug Fixes: 

File->Import: Memory buffers now initialised to zero to avoid occasional error when import.

View Images: ms/s/min time units options now correctly change time units on display.

Bug Fixes:

NPI EPC-03SX: Potential gain now read correctly. Secondary channel (cell potential) now switches between Command Input and Potentisl Output when switching voltage- to current-clamp mode.

Heka EPC-9 USB: Change to amplifier initialisation to fix amplifier initialisation errror with EPC-9 and USB interface.

Heka EPC-10-USB: lih88driver.dll now included in program folder.

Updates:

Axopatch 200 and AMS-2400: Switching of secondary (potential) input channels between amplifier current/voltage outputs when changing between voltage- and current-clamp mode can now be accomplished by software mapping of analogue inputs.

Bug Fixes:

Bug Fixes:

D igidata 1440/1550/1550A: wdapi1140.dll now correctly loaded under Windows XP operating system.

File Open: File name box in file open dialog now cleared to ensure that available files are displayed.

Bug Fixes:

Digidata 1440/1550/1550A: Now loads DLLs from C:\Users\Public\Documents\SESLABIO rather than WinWCP program folder. 

XML Settings files: Now ensures no. of input channels >= 1 when loaded from settings file. XML settings file now checked for settings records to avoid access violation if not present.

Bug Fixes:

Edit->Copy Data: Data point arrays > 10000 points now compressed to less than 20000 before copying to clipboard.

Bug Fixes:

Digidata 1440/1550/1550A: Now works correctly again on older systems. DLL files now obtained from PCLAMP or AXoSCOPE program folders.

OptoPatch: Now correctly sets units of voltage channel.

Export: No longer corrupts long export file names.

Updates:

DCLAMP: Dynamic clamp control panel added.

Tecella patch clamps: Gain settings can now be corrected using manual user-supplied correction table C:\Users\Public\Documents\SESLABIO\tecella gain correction table.txt

Bug Fixes:

Tecella patch clamps: Now works correctly with Triton+, supporting 16 channels.

Data Files: No. of samples reported in data file header now corrected if it does not match actual number of samples in file.

Updates:

Export: Matlab .MAT data file added to list of export file formats.

Updates:

Single Channel Analysis: Event durations, amplitudes and standard deviation can now be exported as an Export Event List option. Average event amplitude vs closed time and Average event amplitude vs Dwell time plots added to stability plot page.

Bug Fixes:

Protocol Editor: Settings of last changed waveform element no longer reset to default when a new element added to waveform sequence.

Amplifiers (Axoclamp 2): current stimulus output on AO1 now correctly scaled.

Amplifiers (Multiclamp 700A/B): Communications link between WinWCP and Multiclamp Commander can be re-established by selected Setup->Reset Multiclamp 700A/B Link.

Bug Fix:

Bug Fix:

Bug Fix:

Bug Fix:

ITC-16/18: Support updated to fix problem with WinWCP should not affect WinEDR.

Bug Fix:

Current scaling factor for Axoclamp 2 command current channel (AO1) now recognised correctly.

Updates:

National Instruments: PCI-6281 and other 18 bit resolution interfaces now supported.

Amplifiers: Heka EPC9/10 and NPI ELC03SX now supported.

Axon ABF Files: ABF V2.X files can now be imported.

Updates:

National Instruments: Support for USB-6000 - USB-6005 devices added.

Bug Fixes:

Amplifier Settings.xml files now loaded correctly from settings folder (C:\Users\Public\Documents\WinEDR).

Bug fixes:

Amplifier Settings.xml and Tecella Settings.xml files now stored in settings folder (C:\Users\Public\Documents\WinEDR) rather than WinEDR program folder. Avoids file write error on program exit when user does not have administrator privileges.

Bug fixes:

Digidata 1440A Recording sweeps no longer hang up after external trigger.

Amplifiers: Current command scale factors settings now recognised. Amplifier settings now saved and reloaded from file correctly.

Updates:
Data File Names: New data files created while recording to handle sampling rate / channel number changes now appended with sequence numbers .nnn rather than ++++.

Updates:

Digidata 132X, 1440, CED 1401, ITC-16/18 interfaces: Analog input channels 0..15 can now be mapped to user-selected physical input channels on interface.

CED 1401: Power 1401 Mk3 now supported.

Bug Fixes:

Floating point error when importing Chart .CHT files fixed.

Updates:

Stimulus Editor: New stimulus protocol editor (up to 4 analog output channels, digital outputs can have multiple waveforms), current stimuli supported.

Laboratory Interfaces: Tecella PICO patch clamp now supported.

Amplifiers: New amplifiers setup page

Digital Filters: Filtered signals can now be output to new signal channels instead of overwriting existing channel.

Export: Individual signal channels can now be selected for export. Zero level is now subtracted from signals in ASCII file export.

Bug Fixes:

Single-channel analysis: Amplitude histograms can now be imported from list in external files.

Bug Fixes:

Single-channel analysis module: Error in scaling of amplitude histograms which occured when bin widths at the lower limit of the bin width range were selected fixed.

Max. number of bins / histograms increased to 4000 and lower bin width limit set to amplitude resolution.

Initial parameter guesses for gaussian fits improved.

Mean current and open channel probability stability plots now only plot means of complete averaging blocks. Incomplete blocks at end of plots are now discarded.

Bug Fixes:

Amplitude of signals in records exported from event detector to WCP files now scaled correctly.

Updates:

National Instruments I/O boards: Min./max. sampling rates and availability of analog and digital outputs now determined from device information in library (requires NIDAQ-mx V8 or newer).

Bug Fixes:

Event Detector:  Two frequency plot variables are now available - the instantaneous event frequency (Frequency (inst.)) computed from inter-event intervals and the average event frequency (Frequency (avg)) computed from the number of events counted during defined intervals throughout the recording. (Frequency (avg) replaces the Interval Average frequency option which produced a frequency average with from a count during  a variable interval.)

Recording To Disk: The settings for the real time cell resistance monitor option are now retained in the EDR.INI file.

Updates:

Event Detector: Detected events now aligned by mid-point of rising edge (size of search window for rising edge can be set by user).

Bug Fixes:

Event Detector: Memory access violation error when baseline adjustment selected now fixed.

12/01/10
WinEDR
V3.1.1

Updates:

16 analog channels now supported.
No. of bins, bin width and bin range can be set for histograms.
WinEDR and WinWCP data files now have different icons.

Bug Fixes:

Current scaling factor for Axoclamp 2 now correct and support for HS1, HS10 and HS0.1 headstages added.

Bug Fixes:

Digital filter: Notch filter now works correctly when notch frequency is a small fraction of sampling rate.

Noise Analysis: Memory violation when copying data in variance vs time plots with 4000 data points fixed.

Bug Fixes:

Bug introduced in V3.0.5 which caused WinEDR to crash without warning when changing duration of detected events display and at other times within event detection module fixed.

Minimum display window size reduced from 1 sec to 50 ms.

Cell resistance measurement plot added to recording window.

Size of user-defined waveform stimuli no longer limited to 1024 points and can now be loaded from a file.

Event Detector: Exported event record size limit increased to 1048576 total sample points. Event detector event list size increased to 1000000.

Notes can be added to in log window (log file no longer directly editable from with WinEDR).

File ident line now changeable in Record and Edit Markers / Line box (not in View windows).

Bug Fixes:

Size of EDR.INI increased to accommodate large file paths (fixes Array Full error).

Bug Fixes:

Molecular Devices Digidata 1440 interface unit now detected.

Bug Fixes:

Export of large files to ABF and other file types no longer produces Out of Memory error.

NPI Turbo-Tec03X gain scaling is now correct at all values.

Updates:

Update of signal readout in recording window now slower to make it easier to read.

19/8/08
WinEDR
V2.9.7 

Updates:

Signal display windows updated. Channels can be hidden and resized. Number and size of Y axis calibration ticks now better chosen.

Support for full range of NPI Turbo-TEC amplifiers added.

Two patch clamp amplifers now supported.

Bug Fixes:

Bug in import from CFS file which caused repetition of data fixed.

 Bug Fixes:

Single-channel within bursts open probabiliity (Po) now calculated correctly.

Rate of rise and other event detection criterion signals within event detector window now kept within 16 bit digital sample limit, avoiding signal wrap-round problems with large rapidly changing signals.

 

Bug Fixes:

EDR data files with spaces in their names can now be opened in WinEDR by double-clicking on the files.

The message "Unable to create log file" no longer appears when more than one copy of WinEDR is running.

The file header array full warning now only occurs once.

Updates:
A/D & D/A Buffer size with National Instruments NIDAQ-MX library now increased to 1.2Mbyte, allowing longer stimulus programs while retaining short (1ms) pulses.

Bug Fixes:
Vertical magnification box now has a minimum size of 8 pixels, to avoid accidental changes in magnification.
Digidata 1320 no longer calibrated when program is started to avoid "unable to calibrate" error.

21/08/07
WinEDR
V2.8.5

Updates
No. of points averaged to calculate detected waveform zero level in event detector can now be set by user. A gap can also be left between start of record/event and zero level block.

20/08/07
WinEDR
V2.8.4

Updates
Vertical magnification of signal displays now faster and easier to adjust with mouse. Display zoom in/out, up/down buttons added.

Bug Fixes
Errors when event detector display duration set to a large value fixed. 

WinEDR

V2.8.3

Updates

Stimulus protocol generator enhanced. Two DAC channels now supported. Complex wave shapes and sequences can be generated and protocols can be linked together. Digital outputs available with National Instruments M Series interfaces units.

ASCII text files exported from HEKA Pulse program can now be imported.

COM automation interface added allowing recording and seal test functions to be controlled from VBSCRIPT script file.

17/04/07

WinEDR

V2.8.2

Bug Fixes

Spurious pulse which appeared intermittently at end of recording sweeps with ITC-16/18 interfaces now fixed for both old and new ITC16/18 drivers.

14/04/07

WinEDR

V2.8.1

Bug Fixes

Spurious pulse which appeared intermittently at end of recording sweeps with ITC-16/18 interfaces fixed.

National Instruments devices without digital I/O support (e.g. USB6215) no longer trigger unnecessary errors messages.

09/03/07

WinEDR

V2.8.0

Updates

Event Detection: Options added to allow event decay time to be measured relative to mid-point of signal rising phase or a0 cursor, as well as from peak of signal. Option added to allow signal zero level to be set from start of event window as well as immediately preceding event.

Bug Fixes.

Event Detection: Errors in scaling of signal amplitude when detected event signals with multiple channel exported to WCP files fixed.

04/02/2007

WinEDR

V2.7.9

Updates

Peak detection for waveform analysis of detected event can now be restricted to a region defined by analysis cursors to exclude artefacts.

Bug Fixes

Amplitude of channels imported from WCP now scaled correctly. CFS files with empty channels containing zero points can now be imported. 

22/12/2006

WinEDR

V2.7.8

Updates:

Manual cursors measurements of single-channel currents now saved in interna list and can be plotted as stability plots or as amplitude histograms.

Single-channels can now be include/excluded from analysis using current amplitude standard deviation as a criterion.

Bug Fixes:

Export to IGOR Binary Wave format files now works.

03/12/06

WinEDR

V2.7.7

28/11/06

WinEDR

V2.7.6

Updates:

Linear fit added to Event detector module event waveform average

Bug Fixes:

Detected event list now updated after events are added or deleted, to avoid corruption of event list when display channel is changed after an event is deleted.

27/11/06

WinEDR

V2.7.5

Updates:

Event detector module: Post-peak decay time measurement (T/90%) now allows user to set % decay time (T.x%).

Single-channel module: i) Exclusion of edge points in single-channel current amplitude now set in Edit state windows and applied consistently on other plots and histograms. ii) Manual cursor measurements of event duration and amplitudes can be exported to a file. Max. duration of display windows increased

Bug fixes:

ABF files exported from WinEDR no longer causes error when digital filter applied in CLAMPFIT. 

27/09/6

WinEDR

V2.7.3

Updates:

Support for voltage-current clamp mode switching added. 

16/06/6

WinEDR

V2.6.9

Updates:

Axopatch 200 current/voltage channel changing when switching between voltage- and current clamp mode now supported. Support for Warner PC501A and 505B amplifiers added.

Single-channel current amplitude stability plot added to single-channel analysis module

Count-matched averaging option added to event detection module

Bug Fixes:

Digidata 1200 support now works again under Windows 9X (using pre V2.6.6 WinRT drivers)

09/06/6

WinEDR

V2.6.7

Updates:

Single-channel current stability plot added to single-channel analysis module.

Bug Fixes:

Resizing display window while recording is in progress no longer causes the loss of A/D samples from the recording.

Bug which caused termination of A/D display at certain sampling intervals fixed. 

12/4/6

WinEDR

V2.6.6

Updates:

Axon Digidata 1200 card now supported under Windows NT, 2000 and XP

Support for Dagan 3900A and PC-One patch clamps added

Non-linear baseline trends can now be subtracted from detected event signals

Bug Fixes:

Time and amplitude scaling of signals imported from IGOR IBW files now correct 

29/5/5

WinEDR

V2.5.9

Updates:

National Instruments card analogue input modes can now be set to differential or NRSE from within WinEDR.

Bug Fixes:

NPI SEC 05LX single-electrode clamp gain telegraph now read correctly.

19/5/5

WinEDR

V2.5.8

Updates:

Strathclyde Chart and Microsoft WAVE format files can now be imported and exported.

Support for NPI SEC 05LX single-electrode clamp added.

Bug Fixes:

Seal Test now works with Standard 1401 again

Time units for ASCII text file import now works correctly.

16/5/5

WinEDR
V2.5.7

Updates:

WinEDR can now be updated without manually uninstalling previous versions.

Bug Fixes:

Pre-existing channel scale settings for a file containing data is no longer overwritten within Recording Setup.

Bug introduced in previous update which prevented Recording to Disk with Digidata 1200 now fixed.

25/4/5

WinEDR

V2.5.5

Updates:

Support for National Instruments M Series cards added.

Bug fixes:

Patch clamp amplifier gain telegraph should now be read correctly using Axon Digidata 1320 Series interface unit. 

9/3/5

WinEDR
V2.5.4

Updates:

High pass and notch digital filter added.

Channels can now be filtered separately.

Bug fixes:

Stimulator option now work.

Cairn Optopatch and A-Systems support should now work correctly. 

20/12/4

WinEDR V2.5.2

Updates:

Support for Biologic RK400, A-M Systems 2400 & NPI Turbo Tec added.

Amplitude histograms now displayed with better X axis range.

Curve fit results can be saved to log file.

9/8/04

WinEDR

V2.4.9

Updates:

Axon Multiclamp 700A & 700B amplifiers now supported.

External trigger now supports both Active High and Low trigger polarities.

Bug Fixes:

VP500 holding current now in pA rather than nA.

VP500 CFast compensation now more reliable.

14/4/04

WinEDR

V2.4.8

Updates:

Support for Biologic VP500 patch clamp added.

Incrementing index numbers automatically added to names of new data files

25/3/04

WinEDR

V2.4.7

Updates:

Import/export of Igor binary files added.

Bug Fixes:

Seal Test window floating point errors now trapped.