SIPBS - University of Strathclyde
  Strathclyde Institute of Pharmacy and Biomedical Sciences

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Infection, Immunity and Microbiology

Overview
Infection, immunity and microbiology is a vibrant research group focused upon infection and immunity in human and animal populations. We strive to understand the physiology and molecular pathogenesis of the infective agents in order to develop and characterise appropriate vaccines, novel adjuvants and biopharmaceuticals. Another key area is in the immuno-pathogenesis and immuno-modulation of e.g. allergic, autoimmune and cardiovascular diseases. The group houses the Strathclyde Fermentation Centre and has strong links with the Centre for Biophotonics.

Pathogens/model organisms under study: Acanthomoeba, Acanthocheilonema, Aspergillus, Corynebacterium, Escherichia, Leishmania, Myobacterium, Pichia, Pseudomonas, Salmonella, Shigella, Streptomyces, Toxoplasma, Trichomonas, Vibrio.

Group Leader
Dr Martin Wiese
Email: martin.wiese@strath.ac.uk

Staff involved

Professor James Alexander [immunology,vaccinology, Leishmania], Dr Katharine Carter [Leishmania], Professor Graham Coombs [Leishmania, Trichomonas, biochemistry], Dr Geoff Coxon [tuberculosis, medicinal chemistry], Professor William Harnett [immunology, helminthology], Dr Linda Harvey [Bioprocessing], Dr Paul Herron [molecular bacteriology], Dr Paul Hoskisson [bacterial molecular physiology], Dr Hui-Rong Jiang [immunology], Dr Catherine Lawrence [helminthology, mast cells], Dr Alan McCruden [immunology], Professor Brian McNeil [bioprocessing], Dr Owain Millington [immunology, Leishmania], Professor Craig Roberts [molecular parasitology, immunology, Toxoplasma], Dr Dino Rotondo [inflammatory responses], Dr Veronique Seidel [natural products chemistry, antibiotic discovery], Dr Nicholas Tucker [bacteriology, biochemistry], Dr Martin Wiese [Leishmania, protein kinases], Dr Jun Yu [molecular pathogenesis of bacterial infection].


Postgraduate Research Opportunities

Characterisation of the Control of Inflammatory Responses in Human Immune cells
Measuring enzyme activity in Leishmania infected macrophages using SERRS
New drugs for bad bugs: Manipulation of antibiotic biosynthetic pathways for better drugs
Targeting the nematode carbohydrate: phosphorylcholine transferase
Coordination of DNA replication with hyphal growth in the antibiotic producing bacterium Streptomyces coelicolor
Determining immune control of infection versus autoimmunity
Investigating the distinct roles of dendritic cells and macrophages in immunity using a Leishmania mexicana infection model
Developing lab-on-a-chip tools to investigate individual immune cell interactions
Role of mast cells in inflammatory arthritis
Mast cells in gastrointestinal helminth infection
Examining the antibiotic potential of legumes
Development of a Mucosal Anti-fertility Device Based on Metal Nanoparticles
Understanding metabolic and genetic changes on scale translation of natural isolates