Funded opportunities currently available within the Institute Continuous Chiral Resolution by Integration of Membrane and Crystallisation Technologies Other Projects available New Medicines: Fundamentals : Role of building design in house dust mite colonization and development of asthma A multidisciplinary approach to elucidate the mechanism of ammonium transport by the ubiquitous family of Amt/Rhesus protein A new role for the Gelsolin family in the regulation of G protein-coupled receptors (GPCR) activity Age-related and cell-type specific neural information processing Anti-parasitical drug targeting and validation Bitter taste receptor mediated relaxation of smooth muscle Characterisation of novel clinical targets for treating pulmonary vascular disease Characterising the potential neuroprotective properties of protease-activated receptor 2 (PAR2) activators in animal models of brain inflammation? Coordination of chromosome segregation during spore germination of the antibiotic producing bacterium, Streptomyces coelicolor Does mitogen-activated protein kinase phosphatases (MKP-2) play a critical role in glial proliferation and synaptic maturation? Effect of Sesquiterpenes on Vascular Smooth Muscle and Vascular Endothelial Cell Proliferation, Migration and Viability Exosomal transfer in cardiovascular disease; investigation of novel paracrine cell-cell signalling within the vascular wall Exploring the pharmacology of novel PAR4 pepducins Functional characterisation of cell wall deacetylases in Corynebacterium diphtheriae Modulation of inflammatory arthritis by gastrointestinal helminth infection Neural plasticity in the habenula New drugs for bad bugs: synthetic biology of antibiotic biosynthetic pathways Novel receptor interactions as a target for developing new analgesics Reactive oxygen species-dependent modulation of resistance artery structure and function Regulatory interactions between bacterial core and accessory genomes. Role of mast cells in the development of obesity and diabetes Role of the microbiome in gastrointestinal nematode induced enteropathy. Role of TLR-ligands in polarising the innate immune response in gastrointestinal helminth infection Shark vs Tiger – understanding microbial inter-strain chemical warfare in the quest for novel antimicrobials The involvement of the pulmonary vein in atrial fibrillation and how it is affected by co-morbidities New Medicines: Target Validation and Drug Discovery Alterations in calcium handling in cardiac fibroblasts from diseased hearts Assessing the role of JNK in damage to endothelial cells in response to radiation and anticancer therapy Cellular genetics for the study of human disease, pharmacogenomics, and biology Immunomodulation of Stem Cells in Stroke Investigating mechanisms of cobalt induced neurotoxicity with reference to metal ion release in patients with metal-on-metal hip replacements Investigation of the effects of omega 3 fatty acids on anti-cancer drug mediated cardiotoxicity Is a dose of worms good for you? Application of a parasitic worm product to the treatment of inflammatory diseases Maintenance of mitochondria and ageing via the ULK1 autophagy pathway Molecular and cellular changes in intellectual disability Oxidative stress and vascular dysfunction associated with coronary stents Pharmacological modulation of AMPA receptors in different types of neurons Role of sphingosine 1-phosphate in scleroderma Stem Cells in Stroke The influence of biogeography on marine actinomycetes specialized metabolism Understanding the role of immune molecules in central nervous system diseases Vascular toxicity of anti-cancer tyrosine kinase inhibitors Better Medicines Continuous Chiral Resolution by Integration of Membrane and Crystallisation Technologies Development of novel tumour-targeted nanomedicines entrapping nutraceuticals for cancer therapy Development of novel tumour-targeted nanomedicines for cancer therapy Development of a vaccine against leishmaniasis. Improving the targeting of anti-cancer agents Investigating manufacturing process for liposomal solubilisation agents. Multi-channel high-precision (8ps) stopwatches for ranging and time-resolved spectroscopy applications Phasor approaches for studying endocytosis of gold nanoparticles in cancer cells Secondary Metabolomics of Novel Antibiotics from Marine Microbial Symbionts from Extreme Environments Silk – ancient material for novel medical applications Better Use of Medicines An evaluation of the utilisation pattern and clinical outcomes of the new oral antidiabetic agents in Scotland using real world data