Funded opportunities currently available within the Institute

• Continuous Chiral Resolution by Integration of Membrane and Crystallisation Technologies

Other Projects available

New Medicines: Fundamentals

• : Role of building design in house dust mite colonization and development of asthma
• A multidisciplinary approach to elucidate the mechanism of ammonium transport by the ubiquitous family of Amt/Rhesus protein
• A new role for the Gelsolin family in the regulation of G protein-coupled receptors (GPCR) activity
• Age-related and cell-type specific neural information processing
• Anti-parasitical drug targeting and validation
• Bitter taste receptor mediated relaxation of smooth muscle
• Characterisation of novel clinical targets for treating pulmonary vascular disease
• Characterising the potential neuroprotective properties of protease-activated receptor 2 (PAR2) activators in animal models of brain inflammation?
• Coordination of chromosome segregation during spore germination of the antibiotic producing bacterium, Streptomyces coelicolor
• Does mitogen-activated protein kinase phosphatases (MKP-2) play a critical role in glial proliferation and synaptic maturation?
• Effect of Sesquiterpenes on Vascular Smooth Muscle and Vascular Endothelial Cell Proliferation, Migration and Viability
• Exosomal transfer in cardiovascular disease; investigation of novel paracrine cell-cell signalling within the vascular wall
• Exploring the pharmacology of novel PAR4 pepducins
• Functional characterisation of cell wall deacetylases in Corynebacterium diphtheriae
• Modulation of inflammatory arthritis by gastrointestinal helminth infection
• Neural plasticity in the habenula
• New drugs for bad bugs: synthetic biology of antibiotic biosynthetic pathways
• Novel receptor interactions as a target for developing new analgesics
• Reactive oxygen species-dependent modulation of resistance artery structure and function
• Regulatory interactions between bacterial core and accessory genomes.
• Role of mast cells in the development of obesity and diabetes
• Role of the microbiome in gastrointestinal nematode induced enteropathy.
• Role of TLR-ligands in polarising the innate immune response in gastrointestinal helminth infection
• Shark vs Tiger – understanding microbial inter-strain chemical warfare in the quest for novel antimicrobials
• The involvement of the pulmonary vein in atrial fibrillation and how it is affected by co-morbidities

New Medicines: Target Validation and Drug Discovery

• Alterations in calcium handling in cardiac fibroblasts from diseased hearts
• Assessing the role of JNK in damage to endothelial cells in response to radiation and anticancer therapy
• Cellular genetics for the study of human disease, pharmacogenomics, and biology
• Immunomodulation of Stem Cells in Stroke
• Investigating mechanisms of cobalt induced neurotoxicity with reference to metal ion release in patients with metal-on-metal hip replacements
• Investigation of the effects of omega 3 fatty acids on anti-cancer drug mediated cardiotoxicity
• Is a dose of worms good for you? Application of a parasitic worm product to the treatment of inflammatory diseases
• Maintenance of mitochondria and ageing via the ULK1 autophagy pathway
• Molecular and cellular changes in intellectual disability
• Oxidative stress and vascular dysfunction associated with coronary stents
• Pharmacological modulation of AMPA receptors in different types of neurons
• Role of sphingosine 1-phosphate in scleroderma
• Stem Cells in Stroke
• The influence of biogeography on marine actinomycetes specialized metabolism
• Understanding the role of immune molecules in central nervous system diseases
• Vascular toxicity of anti-cancer tyrosine kinase inhibitors

Better Medicines

• Continuous Chiral Resolution by Integration of Membrane and Crystallisation Technologies
• Development of novel tumour-targeted nanomedicines entrapping nutraceuticals for cancer therapy
• Development of novel tumour-targeted nanomedicines for cancer therapy
• Development of a vaccine against leishmaniasis.
• Improving the targeting of anti-cancer agents
• Investigating manufacturing process for liposomal solubilisation agents.
• Multi-channel high-precision (8ps) stopwatches for ranging and time-resolved spectroscopy applications
• Phasor approaches for studying endocytosis of gold nanoparticles in cancer cells
• Secondary Metabolomics of Novel Antibiotics from Marine Microbial Symbionts from Extreme Environments
• Silk – ancient material for novel medical applications

Better Use of Medicines

• An evaluation of the utilisation pattern and clinical outcomes of the new oral antidiabetic agents in Scotland using real world data