SIPBS - University of Strathclyde
  Strathclyde Institute of Pharmacy and Biomedical Sciences

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Cell Biology

Our research is focused at the understanding of cellular and molecular organisation and function in health and disease.

The following fundamental cellular processes are being investigated within the group.

  • Cell physiology: Drummond, Bushell, Kennedy, MacMillan
  • Signalling: Pyne N, Pyne S, Plevin, Paul, Kennedy, Flint, Bushell, MacMillan
  • Changes in gene expression: Pyne N, Pyne S, Plevin, Paul, Ellis
  • Responses to stress: Plevin, Ellis, Flint
  • Cell death: Bushell, Boyd, Chan, Flint, Ellis
  • Biomarkers for disease processes: Ellis, Pyne N, Pyne S
  • Translational biology: Boyd, Paul, Pyne N, Pyne S, Plevin

The following technologies and expertise are available within the group:

  • Cell culture, including a wide range of cell-based assays and techniques
  • Molecular biology, including Q-RT-PCR, siRNA techniques, cloning, expression systems, protein purification
  • Enzyme assays, signalling assays
  • Biophotonics: McConnell
  • Electrophysiology including expression systems, isolated cells, primary and organotypic neuronal culture and acute brain slices
  • Ca2+ imaging from isolated and intact smooth muscle, primary and organotypic neuronal culture.

Research in Cancer at Strathclyde (RICAS)
We are also leading on the development of this new virtual centre for cancer research which brings together staff across departments and faculties at Strathclyde including cell biologists, drug discovery, drug formulation, chemists and physicists. Please visit the RICAS website for more information.

Group Leader
Professor David Flint
Email: david.flint@strath.ac.uk

Staff involved

Dr Marie Boyd, Dr Luke Chamberlain, Dr Edmond Chan, Dr Susan Currie, Dr Robert Drummond, Dr Elizabeth Ellis, Professor David Flint, Professor Miles Houslay, Dr Charles Kennedy, Dr Debbi MacMillan, Dr Gail McConnell, Dr Alistair Paterson, Dr Andrew Paul, Professor Robin Plevin, Professor Nigel Pyne, Professor Susan Pyne, Dr Rothwelle Tate.


Postgraduate Research Opportunities

Characterisation of novel neurotransmitter signalling mechanism in urinary bladder smooth muscle
Combination therapy for cancer treatment
Super-resolution nonlinear optical microscopy
Effect of sphingosine kinases on the phosphoproteome, ubiquitinome and metabolome in cancer cells
Neuromuscular modulation by AMP-activated protein kinase
The novel role of lysophosphatidylcholine in the modulation of pain sensing neurons
Modelling calcium waves in rat pulmonary vein: are they responsible for triggered cardiac arrhythmias
Characterisation of a novel mechanism for modulating the activity of pain-sensing nerves
Identification of novel sphingosine kinase inhibitors from plants
Regulation of Huntingtin-Interacting Protein HIP14 and Links with Huntington’s Disease
Cell biology project studying the regulation and roles of autophagy in cancer stem cells
The regulation and function of MKP-2 in endothelial cells
Ultrashort pulsed Raman lasers for multiphoton laser scanning microscopy