

Cardiovascular ResearchThe cardiovascular research group is active in the twin research fields of vascular biology and myocardial cell function. These are explored through in vivo models of disease, integrative studies at the organ level, and functional evaluation of cardiovascular cell behaviour. Members of the research group have particular expertise on regulation of subcellular calcium concentrations, structual remodelling, drug-receptor interactions and integrative pharmacology. The research is leading to the identification of novel drug targets, and the evaluation of candidate therapeutic interventions. Staff involvedDr Paul Coats, Dr Susan Coker, Dr Susan Currie, Dr Hilary Carswell, Professor Robert Jones, Dr Debbi MacMillan, Professor John McCarron, Professor Roger Wadsworth. Postgraduate Research OpportunitiesAltered Calcium handling in adult cardiac myocytes and fibroblasts following cardiac hypertrophyModulation of cardiac and cerebral CaMKII following cardiac hypertrophy Imaging changes in mitochondrial architecture and mobility in vascular disease Effects of MKP-2 KO in stroke: defining the role of MAPK cascade in pathogenesis of stroke Endocannabinoids Effects on Stem Cell- Based Recovery After Experimental Stroke: Mechanistic Insight into the Role of Calcium/Calmodulin dependent protein Kinase II Novel mediators of pulmonary hypertension induced by oxidative stress |